Molecular chaperones are a class of proteins responsible for proper folding of a large number of polypeptides in both prokaryotic and eukaryotic cells. Newly synthesized polypeptides are prone to nonspecific interactions, and many of them make toxic aggregates in absence of chaperones. The eukaryotic chaperonin CCT is a large, multisubunit, cylindrical structure having two identical rings stack...

AIMS To investigate by real-time 3D echocardiography (RT3DE) and cardiac computed tomography (CCT) the analysis of left ventricle ejection fraction (LVEF) and volumes. METHODS AND RESULTS A total of 67 patients (37 males, 55 +/- 11 years) were studied prospectively by RT3DE and by 64-slice CCT. RT3DE data: LVEF ranged from 30 to 78.6% (63.1 +/- 7.33); left ventricular end-diastolic volume (LV...

PURPOSE To examine if central corneal thickness (CCT) is different in emmetropia and high myopia. METHODS 57 emmetropic subjects (0 to + 1.5 D) and 48 high myopes (all more than - 6 D in spherical equivalent refraction) were studied. CCT was measured by a Haag-Streit Optical Low-Coherence Reflectometry (OLCR) pachymeter, a recently developed high precision pachymeter with a standard deviation...

BACKGROUND Central corneal thickness (CCT) can be used to assess the corneal physiological condition as well as the pathological changes associated with ocular diseases. It has an influence on the measurement of intraocular pressure and is being used as a screening tool for refractive surgery candidates. The aim of this study was to determine the median CCT among normal Pakistani population and...

STUDY DESIGN Cross-sectional, matched-pair comparative study. PURPOSE To determine whether a thin-sliced pedicular-oriented computed tomography (TPCT) scan reconstructed from an existing conventional computed tomography (CCT) scan is more accurate for identifying vertebral artery groove (VAG) anomalies than CCT. OVERVIEW OF LITERATURE Posterior atlantoaxial transarticular screw fixation and...

purpose: to examine the relationship between retinal nerve fiber layer (rnfl) measurements obtained using scanning laser polarimetry with variable corneal compensation (vcc) and central corneal thickness (cct) measurements using pentacam in myopic patients methods: the study included 45 eyes from 45 myopic patients with intraocular pressure (iop) measurements≤21 mmhg. all participants had norma...

BACKGROUND The aim of the present study was to evaluate usefulness of ultrasonography in assessment of rabbit common calcanean tendon, to describe its ultrasonographic anatomy and to perform morphometric analysis of this structure. MATERIALS AND METHODS Fifteen skeletally-matured New Zealand rabbits were used in the study. Ultrasonographic examinations of common calcanean tendon (CCT) were pe...

PURPOSE/OBJECTIVES To examine differences in opportunity and eligibility for cancer clinical trial (CCT) participation based on sociodemographic and disease characteristics.
. DESIGN A matched cross-sectional study including a prospective oral questionnaire and retrospective electronic medical record (EMR) review.
. SETTING A single hospital in a large academic National Cancer Institute-des...

PURPOSE To determine if early post-treatment central choroidal thickness (CCT) changes can predict sunset glow fundus (SGF) development in patients with Vogt-Koyanagi-Harada (VKH) disease treated using systemic corticosteroids. METHODS This retrospective case series included 39 eyes of 21 treatment-naïve patients with acute VKH disease who could be followed up for more than 12 months after sy...

To reach a functional and energetically stable conformation, many proteins need molecular helpers called chaperonins. Among the group II chaperonins, CCT proteins provide crucial machinery for the stabilization and proper folding of several proteins in the cytosol of eukaryotic cells through interactions that are subunit-specific and geometry-dependent. CCT proteins are made up of eight differe...