نتایج جستجو برای: ccl22

تعداد نتایج: 1448  

2013
Hidde L. Ploegh Paul-Albert Koenig Eric Spooner Norio Kawamoto

Multiple sclerosis (MS) is an autoimmune disease that affects the CNS. One approved treatment for relapsing forms of MS is YEAK, a random copolymer of the amino acids tyrosine, glutamic acid, alanine, and lysine. YFAK, a second-generation copolymer composed of tyrosine, phenylalanine, alanine, and lysine, is more successful in treating experimental autoimmune encephalomyelitis, a mouse model of...

Journal: :Journal of immunology 2003
Maria-Pilar Armengol Cristina B Cardoso-Schmidt Marco Fernández Xavier Ferrer Ricardo Pujol-Borrell Manel Juan

Chemokines and their corresponding receptors are crucial for the recruitment of lymphocytes into the lymphoid organs and for its organization acting in a multistep process. Tissues affected by autoimmune disease often contain ectopic lymphoid follicles which, in the case of autoimmune thyroid disorders, are highly active and specific for thyroid Ags although its pathogenic role remains unclear....

2016
Yu Yang Fang Liu Miao Tang Miner Yuan Andina Hu Zongyi Zhan Zijing Li Jiaqing Li Xiaoyan Ding Lin Lu

Macrophages play an important role in the development of age-related macular degeneration (AMD). In this study, the spatial and temporal changes and the polarization of macrophages in murine laser-induced choroidal neovascularization (CNV) were investigated, and the polarized M1 and M2 biomarkers in the aqueous humors of neovascular AMD (nAMD) patients were studied. Macrophages, the main infilt...

Journal: :American journal of translational research 2016
Chenggen Xiao Qiaoling Zhou Xiaozhao Li Hui Li Ting Meng Yong Zhong Jiaxi Pu Mengyuan Zhu Yan Xu Lu Gan Hong Sun Ping Xiao

IL-22-producing helper T cells (Th22 cells) have been reported to be involved in lgA nephropathy. However, the mechanisms underlying the differentiation and immune regulation of Th22 cells in lgA nephropathy remain unknown. To elucidate the mechanisms by which Th22 cells differentiate and are recruited into the kidney in lgA nephropathy, the distribution of Th22 cells in both the kidney and blo...

2011
Guang Tan Xin Zhang Hongbo Feng Haifeng Luo Zhongyu Wang

OBJECTIVE This study is to investigate the role of the CIKs cocultured with K-ras-DCs in killing of pancreatic cancer cell lines, PANC-1 (K-ras(+)) and SW1990 (K-ras(-)). METHODS CIKs induced by IFN-γ, IL-2, and anti-CD3 monoantibody, K-ras-DCCIKs obtained by cocultivation of k-ras-DCs and CIKs. Surface markers examined by FACS. IFN-γ IL-12 ,CCL19 and CCL22 detected by ELISA. Proliferation of...

Journal: :Molecules 2016
Chun-Kwok Wong Ida Miu-Ting Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease, associated with basophil infiltration into skin lesions and Staphylococcus aureus (S. aureus)-induced inflammation. Pattern recognition receptors (PRRs), including microbicidal peptide human neutrophil α-defensins (HNP) and dermcidin, can exert immunomodulating activity in innate immunity and skin inflammation. We inve...

Journal: :Multiple sclerosis 2010
J Mellergård M Edström M Vrethem J Ernerudh C Dahle

Natalizumab exerts impressive therapeutic effects in patients with multiple sclerosis (MS). The proposed main mode of action is reducing transmigration of leukocytes into the CNS, but other immunological effects may also be operative. Cytokines and chemokines are involved in the regulation of inflammatory responses and may reflect the disease process in MS. The objective of this study was to ev...

2017
David Capper Andreas von Deimling Alba A. Brandes Antoine F. Carpentier Santosh Kesari Juan M. Sepulveda-Sanchez Helen R. Wheeler Olivier Chinot Lawrence Cher Joachim P. Steinbach Pol Specenier Jordi Rodon Ann Cleverly Claire Smith Ivelina Gueorguieva Colin Miles Susan C. Guba Durisala Desaiah Shawn T. Estrem Michael M. Lahn Wolfgang Wick

Galunisertib, a Transforming growth factor-βRI (TGF-βRI) kinase inhibitor, blocks TGF-β-mediated tumor growth in glioblastoma. In a three-arm study of galunisertib (300 mg/day) monotherapy (intermittent dosing; each cycle =14 days on/14 days off), lomustine monotherapy, and galunisertib plus lomustine therapy, baseline tumor tissue was evaluated to identify markers associated with tumor stage (...

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