Introduction Zoonotic diseases are an important cause of human morbidity and mortality; around 75% of recently emerging human infectious diseases are zoonoses. Herein we report the first seroprevalence study to include a range of emerging or re-emerging zoonotic pathogens of economic concern (including: Bacillus anthracis, Coxiella burnetii, Francisella spp., Brucella spp., and Crimean-Congo he...

Several haemorrhagic fevers are caused by highly pathogenic viruses that must be handled in Biosafety level 4 (BSL-4) containment. These zoonotic infections have an important impact on public health and the development of a rapid and differential diagnosis in case of outbreak in risk areas represents a critical priority. We have demonstrated the potential of a DNA resequencing microarray (Patho...

Background and Aims: Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral disease that occurs in approximately 30 countries. It has the most extensive geographic range among the tick-borne viruses that affect human health. CCHF viruses have a tripartite RNA genome consisting of large (L), medium (M) and small (S) segments. This study was undertaken to determine the genetic relationship of CC...

Crimean-Congo hemorrhagic fever virus (CCHFV), the fatal human pathogen is transmitted to humans by tick bite, or exposure to infected blood or tissues of infected livestock. The CCHFV genome consists of three RNA segments namely, S, M, and L. The unusual large viral L protein has an ovarian tumor (OTU) protease domain located in the N terminus. It is likely that the protein may be autoproteoly...

Bunyaviridae causes a zoonotic disease in many countries of Asia, Africa, the Middle East and south-eastern Europe. As the distribution of CCHFV coincides with the distribution of its main vector, ticks of the genus Hyalomma, the spread of infected ticks into new, unaffected areas facilitates the spread of the virus. The virus circulates in a tick–vertebrate–tick cycle, but can also be transmit...

Background and Aims: Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral disease that occurs in approximately 30 countries. It has the most extensive geographic range among the tick-borne viruses that affect human health. CCHF viruses have a tripartite RNA genome consisting of large (L), medium (M) and small (S) segments. This study was undertaken to determine the genetic relationship of CC...

Expert opinion was elicited to undertake a qualitative risk assessment to estimate the current and future risks to the European Union (EU) from five vector-borne viruses listed by the World Organization for Animal Health. It was predicted that climate change will increase the risk of incursions of African horse sickness virus (AHSV), Crimean-Congo haemorrhagic fever virus (CCHFV) and Rift Valle...

crimean- congo hemorrhagic fever (cchf) is a viral zoonotic tick-born disease with a mortality rate of up to 50% in humans. after a short incubation period, the disease is characterized by sudden fever, chills, severe headache, dizziness, back, and abdominal pain. additional symptoms can include nausea, vomiting, diarrhea, neuropsychiatric, and cardiovascular changes. in severe cases, hemorrhag...

Crimean-Congo hemorrhagic fever virus (CCHFV) is the most geographically widespread of tick-borne viruses. However, African strains CCHFV are poorly represented in sequence databases. In addition, almost all data collected to date have been obtained from cases human disease, while information regarding circulation tick and animal reservoirs severely lacking. Here, we characterize complete codin...