The role of heterozygous galactokinase deficiency in the development of presenile cataracts is presently undetermined. Erythrocyte galactokinase activity was measured from 95 normal Caucasian subjects and from 39 Caucasian patients who had developed idiopathic bilateral cataracts between ages 20 and 55. The diagnosis of heterozygous galactokinase deficiency was based on the following criteria: ...

In a previous study significant glare sensitivity (using Vistech MCT8000) was found only in patients with posterior subcapsular cataracts (PSC) beyond the very early (LOCS II grade 1) stage. The aim of the present study was to evaluate glare sensitivity in patients with early cataracts. The brightness acuity tester (BAT) was used with the Pelli-Robson chart on 50 patients with early cataracts (...

Cataract, defined as opacity of the lens in one or both eyes, is a major cause of blindness throughout the world, and not uncommon, particularly in the elderly population. However, congenital cataracts are rare and occur with a frequency of 30 cases in 100,000 births. About one-third of the cases fall into the group inherited without systemic abnormality. Importantly, congenital cataracts produ...

Dietary exposure to mercury from fish has been posited as a risk factor for cataracts because some reports have suggested methylmercury accumulates in the lens of the eye. But selenium from other dietary sources may offset that damage, according to a study of communities in the Amazon basin [EHP 118(11):1584–1589; Lemire et al.]. The findings, while preliminary, hint at potential public health ...

Congenital cataracts, which are a clinically and genetically heterogeneous group of eye disorders, lead to visual impairment and are a significant cause of blindness in childhood. A major proportion of the causative mutations for congenital cataracts are found in crystallin genes. In the present study, a novel deletion mutation (c.590‑591delAG) in exon 6 of CRYBA1/A3 was identified in a large f...

MYDROASCORBIC (I, 2)) dehydroisoascorbic (2)) and dehydroglucoa scorbic (3) acids will produce a hyperglycemia in rats that persists for weeks. This has been called diabetes. Since dehydroascorbic acid occurs normally in man (4), it is of interest to consider the course of this disease and to further establish the diagnosis of diabetes. Cataracts develop as a complication of human diabetes (5) ...

Treatment of newborn rats and mice with buthionine sulfoximine, an inhibitor of glutathione synthesis, leads to development of cataracts, which are not prevented by treatment with glutathione, but they are prevented by treatment with glutathione monoester. Cataracts are associated with glutathione deficiency in the lens epithelium, which undergoes severe degeneration. The findings indicate that...

Abstract Cataracts are the leading cause of visual impairment and blindness globally. Over years, researchers have achieved significant progress in developing state-of-the-art machine learning techniques for automatic cataract classification grading, aiming to prevent cataracts early improve clinicians’ diagnosis efficiency. This survey provides a comprehensive recent advances classification/gr...

Radiofrequency (RF) energy has been reported to cause a variety of ocular effects, primarily cataracts but also effects on the retina, cornea, and other ocular systems. Cataracts have been observed in experimental animals when one eye was exposed to a localized, very high RF field and the other eye was the unexposed control. The results show that 2450 MHz exposures for >or=30 min at power densi...

Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using plastic embedding with methacrylate. Untreated rats developed nuclear cataracts by 14 days and mature cataracts by 21 days. However, rats treated with the aldose reductase inhibitor sorbinil did not develop any cataractous change for up to 8 months of 50% galactose feedi...