Most of the updates in the 2015 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer center on the systemic therapy front, with a host of newer agents in the mix. At the NCCN 20th Annual Conference, Dr. Andrew J. Armstrong discussed some of the key developments in metastatic castration-resistant and castration-sensitive prostate cancer, particularly the conflictin...

The relationship between castration and reduced male aggression is well established. However, anecdotal observations of male prairie voles (Microtus ochrogaster) suggest that castration does not reduce aggressive behavior. To investigate the role of testicular androgens on aggressive behavior, castrated or gonadally intact male prairie voles were paired in a neutral arena with a gonadally intac...

An isocaloric low-fat diet has been shown to slow androgen-sensitive Los Angeles Prostate Cancer-4 (LAPC-4) tumor growth in a mouse xenograft model. LAPC-4 cells were injected into male severe combined immunodeficient mice. After palpable tumors developed, the mice were divided into three groups, high-fat intact, high-fat castration, and low-fat castration. Tumor latency (18 versus 9 weeks; P <...

• Effects of meloxicam on chronic indicators pain after castration. Cow-calf proximity and home range as novel post-castration. Knife banded calves experienced more acute pain, respectively. Meloxicam did not reduce at the time-points assessed. Proximity have potential to be used pain. One hundred thirty-one 2 mo. old pasture housed Angus cross bull were evaluated for 62 d over two years (Year ...

Pain alleviation associated with surgical castration of piglets is a debated welfare issue. The present study compares the effect different protocols involving analgesia and/or anaesthesia or se...

An appreciable decrease in the contents of prostatic ascorbic acid and dehydroascorbic acid along with an increase in diketogulonic acid was seen in rats ten days after castration. Castration caused a decrease in the activities of such biosynthetic enzymes as L-gulono-gamma-lactone oxidase and D-glucuronolactone-delta-hydrolase with no significant alteration in the activity of L-gulono-gamma-la...

Prostate cancer belongs to the most common malignant tumors in males. Almost in all patients in advanced stage, disease progression occurs despite of castration therapy. Initial treatment of metastatic disease is androgen deprivation therapy. In the case of castration-resistant disease development in asymptomatic patients, it is a combination of abiraterone acetate plus prednisone and in sympto...

The surgical performance in animal patients affected by carcinoma is justified the search for subjects quality of life. Surgical intervention possible due to current technical now available veterinarians. Since a pathology, often rapid evolution, readiness carry out as soon confirmed. In specialized literature, castration also aims minimize occurrence this being therefore indicated tutors. This...

By Nicolas Sayegh, Nishita Tripathi & 13 more. A study on survival outcomes in patients with metastatic castration-sensitive prostate cancer (mCSPC) undergoing intensified androgen deprivation therapy (ADT)

A 6-year-old male crossbred dog was referred to the Veterinary Medical Teaching Hospital of Islamic Azad University of Karaj with the history of abdominal distention, rectal tenesmus and stranguria. Abdominal radiographs and ultrasonography indicated large distended urinary bladder and prostatic enlargement. ECG showed temporary episodes of atrial standstill. The only abnormalities detected by ...