cladribine, an analogue of deoxyadenosine, is highly toxic for both non-dividing and proliferating cells and has shown activity in the treatment of several malignancies. therefore, the aim of the present study is to investigate the cytotoxicity effect of cladribine (2-cda) on the breast cancer cell line, mcf-7 (estrogen receptor positive, er+). mtt assay, annexin v-fluorescein/pi and hoechst 33...

constipation in children is a common health problem affecting 0.7% to 29.6% children across the world. exact etiology for developing symptoms is not clear in children and the majority is considered to have functional constipation. alteration of rectal and pelvic floor function through the brain-gut axis seems to play a crucial role in the etiology. the diagnosis is often a symptom-based clinica...

Hexameric hemoprotein (HTHP) is employed as a scaffold protein for the supramolecular assembly and activation of apoptotic signalling enzyme caspase-9, using short DNA elements modular recruitment domains. Caspase-9 on HTHP platform due to enhanced proximity followed by combinatorial inhibition at high concentrations. The domains allow reversible switching caspase-9 activity state modulatory st...

Sedum middendorffianum Maxim (SMM) is a Korean endemic plant belonging to the Crassulaceae family. This study aimed investigate antitumor effects of SMM extract on human ovarian cancer cells. Among five plants grown in Korea, showed most potent cytotoxicity cells and had little effect normal surface epithelial Furthermore, we revealed that dose-dependently induced apoptosis A2780 SKOV3 The mark...

background: it is well known that the hippocampus, the ca1 pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. recently, it is observed that pentoxifylline has a neuroprotective effect. this study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the p...

introduction: ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. the purpose of this study was investigating the effects of exercise preconditioning on expression of bax, bcl-2, and caspase-3 proteins in hippocampal ca1 neurons after induction of cerebral ischemia. methods: male rats weighing 260-300 g were randomly allocated into three grou...

The present study investigated the possible protective effects of melatonin on Bleomycin, Cisplatin and etoposide (BEP) chemotherapy regimens using immunohistochemistry. Forty male Wistar rats were divided into four groups ten as; group 1 as untreated control; 2 BEP which received three cycles 21 days’ regimen each 0.5¥ dose levels ofBEP (bleomycin 0.75 mg/kg, 7.5 mg/kg cisplatin 1.5 mg/kg)....