Carotid bodies are sensory organs for monitoring arterial oxygen and CO2. Previous studies have shown that chemoreceptor tissue contains substance P (SP) and exogenously administered SP augments chemosensory discharge. In the present study, we examined the physiological importance of SP in carotid body chemoreception by using a selective nonpeptide SP [neurokinin (NK) 1] receptor antagonist CP-...

in this report of 20 patients with 24 carotid body tumors which is the largest series reported so far from iran, we have evaluated the various characteristics of this relatively rare tumor in our population and compared our results with that of the literature. although the prevalence of the tumor is cited to be equal among both sexes, we found a female to male ratio of 2.3 to i, as 14 of our pa...

To determine whether carotid intima media thickness is increased in children with primary hypertension, the current study compared carotid intima media thickness in hypertensive children with that of normotensive control subjects matched closely for body mass index and determined the relationship between carotid intima media thickness and hypertension severity determined by ambulatory blood pre...