the major limitation in the application of bioactive molecule is their low permeation across plasma membrane. in 1988 it was discovered, that a natural polycationic protein, the trans-acting activator of transcription (tat) of the human immunodeficiency virus (hiv-1), passed very efficiently through cell membrane of cultured mammalian cells. tat became known as the first cell penetrating peptid...

Articulated liquid cargo vehicles transporting inflammable fuels and dangerous chemical products require special consideration when traveling on urban roads or cruising at highway speeds. The road safety and handling of these kinds of vehicles may be adversely affected when negotiating sharp turns or travelling on slippery roads, which may result in either lateral instabilities or complete roll...

Global logistics networks have an increasing demand for handling of general cargo. Particularly, huband-spoke networks requires a lot of handling actions in order to realize benefits in comparison to point-topoint networks. The use of automation technologies for improving the handling efficiency is still very challenging because of low standardized logistic processes. Depending on requests of s...

The traditional design approach of grabs and other bulk handling equipment consists manufacturing testing physical prototypes. A novel is to use a co-simulation MultiBody Dynamics (MBD) Discrete Element Method (DEM), in which the virtual prototype new concept interacts with solids. Therefore, this study develops validates full-scale that models grabbing process cohesive stress-history dependent...

The Internet of Things (IoT) is delivering solutions with improved efficiency and security, providing better productivity in manufacturing, retail, other sectors. Maritime Transportation Systems (MTSs) currently adopting the IoT to move toward a digitalized, data-driven world increased lower costs, creating new revenue opportunities. Integration also enables real-time tracking shipments, cargo ...