PURPOSE Cardiac failure due to myocardial iron overload is the most common cause of death in beta-thalassemia patients. Multi/ two echo times-turbo field echo (TE-TFE) magnetic resonance imaging (MRI) is considered the gold standard technique in the evaluation of myocardial iron accumulation. However, multi TE-TFE technique is not available in all scanners. The aim of our study was to show the ...

Patients receiving recurring blood transfusions as supportive therapy to treat chronic anemias, such as myelodysplastic syndromes, thalassemia, and sickle-cell disease, are at risk of iron accumulation. The clinical consequences of iron overload are progressive liver damage, cardiac disease, and endocrine disorders, which can be fatal. Nurses have a vital role in the initial assessment and moni...

INTRODUCTION Iron overload is common in thalassaemia major and sickle cell disease (due to frequent blood transfusions) and in hereditary hemochromatosis. The traditional method to determine total body iron is liver biopsy, as this is the site where iron is first stored. In recent years, non-invasive iron quantification based on MRI [1,2] has been developed, and a FDA-approved T2-based techniqu...

Background T2* measurement is widely used in the assessment of patients at risk for cardiac and hepatic iron overload (1,2). The conventional breath-hold, ECG-triggered, segmented, multi-echo gradient echo sequence (BH MGRE) used for myocardial T2* quantification (3) is very sensitive to respiratory motion and may not be feasible in patients who are unable to breath-hold. To overcome this limit...

Background The management of iron overload has been transformed by the use of T2* as a surrogate marker of cardiac iron loading. The presence of iron however not only changes T2*, but also T2 and T1. Recent advances make T1 mapping a possible complementary technique to T2*. Preliminary data are encouraging, but the relative advantages and disadvantages and optimal mathematical model for the rel...

Background The ability of T2* cardiovascular magnetic resonance (CMR) to identify cardiac iron loading has facilitated a dramatic reduction in mortality in patients with iron overload. There remains a worldwide need for improved access to iron evaluation. One route to achieving this would be simple in-line T2* analysis. We compared our validated T2* methods which use Royal Brompton Hospital (RB...

background: iron is an essential mineral for normal cellular physiology but its ‎overload can lead to cell injury. for many years, deferoxamine injection has been used ‎as an iron chelator for treatment of iron overload. the aim of this study is to compare ‎oral deferoxamine, activated charcoal, and vitamin c, as an absorbent factor of fe, in ‎changing the serum level of iron in iron overload r...

INTRODUCTION Iron cardiomyopathy is a lethal complication of transfusion therapy in thalassemia major. Nutritional supplements decreasing cardiac iron uptake or toxicity would have clinical significance. Murine studies suggest taurine may prevent oxidative damage and inhibit Ca2+-channel-mediated iron transport. We hypothesized that taurine supplementation would decrease cardiac iron-overloaded...

Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy in both adult and pediatric patients with transfusional iron overload. The clinical development program has demonstrated the efficacy of deferasirox for up to 4.5 years of treatment in patients with various underlying anemias, including beta-thalassemia, myelodysplastic syndromes, sickle cell disease, aplast...