HISTORICALLY, BIOMARKERS HAVE BEEN USED IN TWO MAJOR WAYS TO MAINTAIN AND IMPROVE BETTER HEALTH STATUS: first, for diagnostic purposes, and second, as specific targets to treat various diseases. A new era in treatment and even cure for the some diseases using reprograming of somatic cells is about to be born. In this approach, scientists are successfully taking human skin cells (previously cons...

Abstract Heart disease is the leading cause of mortality worldwide. Many cardiac diseases are associated with altered elastic energy relations heart tissue. However, strain functions describing these characteristics limited since they were designed manually for highly specific experimental setups. In this study, we develop CHESRA (Cardiac Hyperelastic Evolutionary Symbolic Regression Algorithm)...

Sudden cardiac death (SCD) accounts for approximately 300,000 cardiac events in the United States each year, representing an overall incidence of 0.1-0.2% per year. Although the vast majority of these may be attributed to coronary atherosclerosis, a wide variety of nonatherosclerotic-related cardiac diseases have been associated with SCD. This review highlights three general categories of cardi...

Neonatal lupus syndrome (NLS) is a rare disease with dermatological, cardiac, hepatic and hematologic involvement due to placental transfer of anti-Ro/ SSA anti-La/ SSB antibodies in infants mothers autoimmune diseases. Multisystemic common infants. Here we present baby neonatal whose mother had Sjögren's syndrome. He presented thrombocytopenia, then convulsion cardiac arrest pericardial tampon...

BACKGROUND It is absolutely necessary to evaluate cardiac function on starting and during hemodialysis in patients with end stage renal disease. In this study, we tried to determinate the changes of cardiac function associated with hemodialysis. METHODS Twenty patients with end stage renal disease, who had been in a hemodialysis program from February, 1997 to August, 1999 in Pusan National Un...

The pathogenesis of cardiac diseases is very complex and involved in many gene transcription and protein expression. How to effectively treat the diseases has become the hotspot of modern medicine. Accumulating evidences over the past decades on integrative medicine have shown us hopeful future prospects. With the development of modern biomedicine, such as sketch mapping genomic sequence, funct...

In order to prevent and treat cardiac diseases, the author proposed strategies to invent cardiovascular drugs targeting cardiac gap junctions through summarizing the functions, physiology and pathophysiology of cardiac gap junctions. The 5 principle strategies to invent cardiovascular drugs that are suggested have great potentialities to be used as novel proposals to treat and prevent cardiac d...

There is a major trade-off between improvements in longevity, general health, fitness and quality of life due to regular intense physical activity on the one hand and possible cardiac risks on the other hand, whether for participants in leisure time sports activities or for highly trained athletes. Cardiac complications and sudden death in sports, even though rare, but dramatic, events, are mai...