In 1939 a program of investigation was undertaken in collaboration with Professor Louis F. Fieser and his associates at Harvard University, directed toward a further study of the chemistry of artificial carcinogenesis. The main task was a biological testing for carcinogenicity of a number of new hydrocarbon derivatives synthesized by Dr. Fieser's group. Although the chief purpose of this paper ...

ln 1969, the International Agency for Research on Cancer (lARe) initiated a programme to evaluate the carcinogenic risk of chemicals to humans and to produce monographs on individual chemicals. The Monographs programme has since been expanded to incIude consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and...

ln 1969, the International Agency for Research on Cancer (lARC) initiated a programme to evaluate the carcinogenic risk of chemicals to humans and to produce monographs on individual chemicals. The Monographs programme has since been expanded to include consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and...

during the past two centuries, production and consumption of nitrate, especially in agricultural field, have been increased considerably. currently many countries in the world including iran encounter to a high nitrate level in drinking water. the main reason is the seepage of agricultural runoff and municipal and industrial wastewater to water resources, particularly groundwater. from the old ...

In 1969, the International Agency for Research on Cancer (IARC) initiated a programme to evaluate the carcinogenic risk of chemicals to humans and to produce monographs on individual chemicals. The Monographs programme has since been expanded to include consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and...

An experimental model developed to investigate premalignant stages of breast cancer was used to establish a rationale for designing experiments that target angiogenesis for cancer prevention. Blood vessels were identified via CD31 immunostaining, and all vessels that occurred in a 50 microm wide region circumscribing each pathology were counted using a digital imaging technique. The blood vesse...

Nonhormonal drugs probably account for only a small proportion of human cancer but have contributed many valuable insights into carcinogenic mechanisms. The antineoplastics, radiopharmaceuticals, and a few other agents account for most of the known drug-induced cancer. A number of other agents are under suspicion, usually due to studies in laboratory animals or to preliminary clinical or epidem...

Occupational cancer is malignant neoplasm caused by exposures to carcinogenic agents at workplace. It is estimated that one out of every three people will subsequently develop cancer during their lifetime in industrialized countries. Undeveloped countries are also at increasing risk due to transfer of hazardous industries. An occupational cancer does not differ either pathologically or clinical...

Widespread losses of heterozygosity (LOH) in human cancer have been thought to result from chromosomal instability caused by mutations affecting DNA repair/genome maintenance. However, the origin of LOH in most tumors is unknown. The present study examined the ability of carcinogenic agents to induce LOH at 53 sites throughout the genome of normal diploid mouse ES cells. Brief exposures to nont...