نتایج جستجو برای: carbon ion therapy

تعداد نتایج: 1120106  

2015
K. Noda T. Furukawa Y. Hara T. Inaniwa Y. Iwata K. Katagiri N. Kanematsu A. Kitagawa K. Mizushima S. Mori T. Murakami M. Muramatsu M. Nakao A. Noda S. Sato T. Shirai E. Takada Y. Takei

The carbon-ion radiotherapy (RT) with HIMAC has been conducted since 1994, and the accumulated treatment number exceeded 9,000 in May 2014. During the last two decades, NIRS has developed both the accelerator and beam-delivery technologies related to the carbon-ion RT, which has brought several carbon-ion RT facilities in Japan. At present, NIRS has developed a carbon-ion rotating gantry with t...

2013
Daniel Habermehl Jürgen Debus Tom Ganten Maria-Katharina Ganten Julia Bauer Ingo C Brecht Stephan Brons Thomas Haberer Martin Haertig Oliver Jäkel Katia Parodi Thomas Welzel Stephanie E Combs

PURPOSE Photon-based radiation therapy does currently not play a major role as local ablative treatment for hepatocellular carcinoma (HCC). Carbon ions offer distinct physical and biological advantages. Due to their inverted dose profile and the high local dose deposition within the Bragg peak, precise dose application and sparing of normal tissue is possible. Furthermore, carbon ions have an i...

The fractal degree of adsorption on the multi-walled carbon nanotube has been investigated. The fractal-like Langmuir kinetics model has been used to obtain the fractal degree of ion adsorption on multi-walled carbon nanotube. The behavior of the fractal-like kinetics equation was compared with some famous rate equations like Langmuir, pseudo-first-order and pseudo-second-order equations. It is...

2011
R. Grün T. Friedrich M. Krämer M. Durante M. Scholz

The promising clinical results of the ion therapy pilot project at GSI have led to an increased interest in carbon therapy with active beam delivery [1]. Carbon ions have an increased biological effectiveness compared to photons. To predict the relative biological effectiveness (RBE) of particles in the irradiated volume the Local Effect Model (LEM I) was developed and used successfully in the ...

2013
Hiroshi Tsuji Toshiyuki Shirai

abbreviated as “Center”) was established in 1993 when NIRS completed construction of the HIMAC. Since then its researchers have been carrying out clinical, biological and physics studies using heavy ions generated from the HIMAC. After accumulating many clinical experiences for carbon ion radiotherapy in various types of malignant tumors, the Center successfully obtained approval from the Minis...

2016
Eun Ho Kim Mi-Sook Kim Yoshiya Furusawa Akiko Uzawa Soorim Han Won-Gyun Jung Sei Sai

The purpose of this study was to investigate the effect of metformin on the responses of hepatocellular carcinoma (HCC) cells to γ-rays (low-linear energy transfer (LET) radiation) and carbon-ion beams (high-LET radiation). HCC cells were pretreated with metformin and exposed to a single dose of γ-rays or carbon ion beams. Metformin treatment increased radiation-induced clonogenic cell death, D...

2016
Atsushi Musha Jun-ichi Saitoh Katsuyuki Shirai Satoshi Yokoo Tatsuya Ohno Takashi Nakano

BACKGROUND Oral mucosal melanoma is a rare disease with a relatively poor prognosis. Carbon ion radiotherapy has been shown to be effective against radiotherapy-resistant tumors owing to its excellent dose concentration and high biological effect. CASE PRESENTATION Our patient was a 66-year-old Japanese man with oral mucosal melanoma of his right maxillary gingiva (T4aN0M0). He received carbo...

2012
Stephanie E Combs Kerstin A Kessel Klaus Herfarth Alexandra Jensen Susanne Oertel Claudia Blattmann Swantje Ecker Angelika Hoess Eike Martin Olaf Witt Oliver Jäkel Andreas E Kulozik Jürgen Debus

BACKGROUND To report on establishment of workflow and clinical results of particle therapy at the Heidelberg Ion Therapy Center. MATERIALS AND METHODS We treated 36 pediatric patients (aged 21 or younger) with particle therapy at HIT. Median age was 12 years (range 2-21 years), five patients (14%) were younger than 5 years of age. Indications included pilocytic astrocytoma, parameningeal and ...

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