ion from the a-carbon or the b-carbon of a disulfide, followed by b-cleavages yielding C–S or S–S bond scissions. The current mechanistic findings should be generally applicable to other radicaldriven disulfide bond cleavages with different radical species such as the benzyl and methyl pyridyl radicals.

Records of blood pressure and body weight of CS2 workers were analyzed in relation to the levels of CS2 exposure at a Japanese rayon-producing fac tory. A cohort of 46 CS2 workers who had later been transferred to non-CS2 jobs showed first a statistically significant rise, which was then followed by two consecutive episodes of statistically significant falls in systolic blood pressure. These ep...

Strains of Rhizobium meliloti, Rhizobium sp. nodulating cowpeas, and R. phaseoli derived from cultures susceptible to tetramethylthiuram disulfide (thiram), 2,3-dichloro-1,4-naphthoquinone (phygon), and 2,3,5,6-tetrachloro-p-benzoquinone (spergon), respectively, grew in the presence of high concentrations of the fungicides and converted them to products not toxic to the sensitive rhizobia. The ...

OBJECTIVE A prospective cohort study was designed to clarify the relations between occupational exposure to carbon disulphide (CS2) and its effects on arteriosclerosis in workers in 11 Japanese rayon manufacturing factories. This report is a cross sectional baseline observation in the first study year. METHODS Study subjects were 432 male rayon workers (mean (range) age 35.5 (19.1-47.8); dura...

Certain functions of the peripheral and autonomic nervous systems, and colour discrimination were examined in 45 workers (mean age 49; mean exposure to carbon disulphide (CS2) 20 years) and 37 controls (mean age 48). Conduction velocity and refractory period of the peroneal and sural nerves were determined. The conduction velocity of the slower fibres of the peroneal nerve was measured by means...

AIMS To clarify whether the current occupational exposure limit (OEL) for carbon disulphide (CS2) is low enough to prevent the occurrence of adverse effects on the cerebrovascular system. METHODS A total of 432 male workers exposed to CS2 and 402 male referent workers in 11 Japanese viscose rayon factories were studied at baseline; 750 of these were followed up. Brain MRI was performed at bot...

A new, convenient and efficient transition metal-free synthesis of S-alkyl dithiocarbamates through one-pot reaction of N-tosylhydrazones, carbon disulfide and amines is reported. Tosylhydrazones derived from various aromatic and aliphatic ketones or aldehydes were tested and gave dithiocarbamates in good to excellent yields. The tosylhydrazones can be generated in situ without isolation, which...

20 Paired associative stimulation (PAS) of the motor cortex leads to increased motor evoked potential 21 (MEP) amplitudes in the stimulated hand muscles. We hypothesized that evoking GABA A receptor-22 mediated short-interval intracortical inhibition (SICI) simultaneously with excitatory PAS would depress 23 long-term potentiation plasticity in motor cortex. Four different PAS paradigms were te...

Idiopathic Parkinson’s disease (IPD), first described by James Parkinson in 1817, is a sporadic neurodegenerative disorder. The main clinical features include masked face, resting tremor, bradykinesia, rigidity, festinating gait, and loss of postural reflexes. The clinical features are most insidious and usually asymmetric at onset. The asymmetry may persist even in a late stage and progress sl...