Long-term facilitation at the crayfish opener muscle is elicited by prolonged high frequency stimulation, and arises from an increase in functional active zones, resulting in increased transmitter release. LTF induction depends critically upon presynaptic calcium accumulation and calcineurin (PP2B) activity. The protein synthesis dependence of this synaptic strengthening was investigated. LTF o...

With the ever-increasing demands for integration of advanced electronic functions into large-area electronics, down-scaling of thin-film transistors (TFTs) becomes very necessary. The key device operational issues associated with TFT scaling, including short-channel effects (SCEs) and self-heating, are considered in this paper. Device structure engineering approaches are introduced to suppress ...

A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice in vivo. After s.c. or i.p. injection of saline solution (in control groups) o...

Algal biorefinery process utilizes every component of algal biomass to produce multiple useful fuel products. In this technique, acid pretreatment of algal biomass hydrolyzes microalgal carbohydrates into fermentable sugars, makes lipids more extractable and a protein part accessible for additional products. In the present study, Chlorella sorkiniana produced higher quantity of biodiesel than B...

conclusions this study does not support the use of emla for hsg. results there was no significant difference in the efficacy between emla and placebo creams in pain perception during the entire procedure. there was no significant difference in long term pain perception half an hour after the hsg performance. patients and methods eighty patients undergoing hsg as part of infertility evaluation w...

We previously reported the identification of human CAP, a protein that is related to the Saccharomyces cerevisiae and Schizosaccharomyces pombe adenylyl cyclase-associated CAP proteins. The two yeast CAP proteins have similar functions: the N-terminal domains are required for the normal function of adenylyl cyclase, while loss of the C-terminal domains result in morphological and nutritional de...

[1] Many Hesperian outflow channels head at elevations compatible with aquifer recharge beneath the Martian south polar cap, and such channels are widely interpreted as the products of this recharge. Some outflow channels head at greater elevations that are inconsistent with southern recharge, including three systems located in Aurorae Planum and eastern Ophir Planum. These three systems have p...

The objective of this study was to formulate and evaluate the drug-polymer interaction of mefenamic acid (MA) using two polymers with different characteristics as ethylcellulose (EC) and/or cellulose acetate phthalate (CAP). Microspheres were prepared by the modified emulsion solvent evaporation (MESE). The effect of drug-polymer interaction was studied for each of microspheres. Important param...

The host-selective AAL toxins secreted by Alternaria alternata f sp lycopersici are primary chemical determinants in the Alternaria stem canker disease of tomato. The AAL toxins are members of a new class of sphinganine analog mycotoxins that cause cell death in both animals and plants. Here, we report detection of stereotypic hallmarks of apoptosis during cell death induced by these toxins in ...