INTRODUCTION The orbit may be directly involved by neoplasms or other destructive processes arising from the orbital contents, the osseous framework or, indirectly, as extensions of extraorbital tumors from the sinuses or cranial vault. In most osseous neoplasms of the orbit, and in tumors with extension into the orbit from surrounding areas, resection of part or all of the orbital walls will b...

BACKGROUND Calvarial lesions are often detected incidentally in routine radiology. Most lytic lesions of the skull are benign. Enlarged parietal foramina are benign lesions caused by deficient intramembranous ossification. CASE REPORT An 11 month-old female patient was admitted with a mass on the right of the back of the head. Physical examination showed a soft 5 cm mass area with no palpable...

Periosteum is a source of osteoprogenitor cells and some investigators advocated the effective use of periosteum as a grafting material for the repair of bone and joint defects. In the present study, we showed bone formation induced from cultured periosteum-derived cells (CPDC) in the rat calvarial defect model. Periosteum taken from a rat tibia was immediately placed in culture medium with 10%...

The art of interpreting skull radiographs is slowly being lost as trainees in radiology see fewer plain radiographs and depend more heavily on computed tomography and magnetic resonance imaging. Nevertheless, skull radiographs still provide significant information that is helpful in finding pathologic conditions and appreciating their extents. Abnormalities in the skull may be reflected as vari...

Among the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with x...

INTRODUCTION Adequate migration and differentiation of mesenchymal stem cells is essential for regeneration of large bone defects. To achieve this, modern graft materials are becoming increasingly important. Among them, electrospun nanofiber scaffolds are a promising approach, because of their high physical porosity and potential to mimic the extracellular matrix (ECM). MATERIALS AND METHODS ...

Endogenous molecular and cellular mediators modulate tissue repair and regeneration. We have recently described antibody mediated osseous regeneration (AMOR) as a novel strategy for bioengineering bone in rat calvarial defect. This entails application of anti-BMP-2 antibodies capable of in vivo capturing of endogenous osteogenic BMPs (BMP-2, BMP-4, and BMP-7). The present study sought to invest...

Emerging evidence suggests that extracellular vesicles (EVs) are secreted by diverse tissues and play important roles in cell-cell communication, organ interactions and tissue homeostasis. Studies have reported the use of EVs to stimulate tissue regeneration, such as hepatic cell regeneration, and to treat diseases, such as pulmonary hypertension. However, little is known about the osteogenic e...