Objective Many previous studies have demonstrated that neuromyelitis optica (NMO) patients have abnormalities of brain anatomy and function. However, differences in spontaneous brain activity between myelin oligodendrocyte glycoprotein (MOG)-IgG ON and aquaporin 4(AQP4)-neuromyelitis optica-optic neuritis (ON) remain unknown. In the current study, we investigated the brain neural homogeneity in...

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may oc...

Neuromyelitis optica (NMO or Devic's syndrome) is a rare demyelinating disease of the CNS that predominantly affects the spinal cord and optic nerves and shares many clinical and radiological features with multiple sclerosis (MS). The association of NMO with autoimmune thyroiditis has been reported very rarely. Early differentiation between NMO and MS is very important because they have differe...

Abstract NaTi 2 (PO 4 ) 3 (NTP) and Na 0.44 MnO (NMO), their derivatives, have emerged as the most promising materials for aqueous Na‐ion batteries. For both, NTP NMO, avoiding evolution of hydrogen oxygen is found to be mandatory in order mitigate material dissolution. Intriguingly, however, no direct determination reactions (HER OER) has yet been carried out. Using differential electrochemica...

NMO-IgG is a disease-specific autoantibody for neuromyelitis optica (NMO) and its target antigen is aquaporin-4 (AQP4) water channel. Recently, we established a sensitive anti-AQP4 antibody assay using human AQP4-transfected cells, which appeared more sensitive than the original NMO-IgG assay. So far, there has been no large-scale study on anti-AQP4 antibody titre in NMO and related disorders. ...

The treatment of neuromyelitis optica (NMO) should be considerably different between the acute phase and chronic phase. In the acute phase, steroid pulse therapy with high-dose methylprednisolone is the first-line therapy to achieve swift remission and to prevent irreversible disabilities. If one or two courses of steroid pulse therapy are insufficient, plasma exchange should be urgently consid...

BACKGROUND Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS), which is characterized by the presence of pathogenic serum autoantibodies against aquaporin 4 (AQP4) in the vast majority of patients. The contribution of T cells to the formation of astrocyte destructive lesions is currently unclear. However, active human NMO lesions contain CD4+...

Results A total of 210 (161 females, 49 males) SLE patients were indentified, 39 of which had manifestations of potential CNS involvement and underwent imaging of their CNS including spinal cord. Three were indentified with probable Devic syndrome, which was confirmed in two (0.9%). Both patients were adolescent females and of Caucasian origin. In one patient NMO was the first manifestation of ...

Background: There are several methods to detect AQP4-antibody which is essential for diagnosis neuromyelitis optica (NMO). Objective: To evaluate an accuracy of the commercially available kit compared with other available tests. Methods: One hundred and twelve patients who visited the multiple sclerosis (MS) clinic at Siriraj Hospital were tested for AQP4-antibody by cell-based assay with Senda...

BACKGROUND Neuromyelitis optica (NMO) is a rare demyelinating disease of the central nervous system that most often results in selective involvement of the optic nerves and spinal cord. Although most cases are sporadic, several familial cases have been reported. All of those patients have been siblings who experienced disease onset at similar ages. To our knowledge, there has not been a documen...