Serum calcitonin was determined by RIA in 59 healthy subjects (Group 1), 49 randomly selected patients with treated or untreated thyroid disorders (Group 2), and in 12 kindred of a pheochromocytoma index case (Group 3). Although most subjects in Group 2 had normal calcitonin levels, there were significant (p less than 0.001) differences between all three groups. Of the five patients in Group 2 ...

Calcitonin and ·-CGRP are products of the alternatively spliced gene CALCA. Calcitonin (CALC) mRNA is predominantly found in thyrodial C cells and mRNA encoding the neuropeptide calcitonin gene-related peptide (CGRP) in neural tissues (Amara et al., 1982, Rosenfeld et al., 1983). In vivo, calcitonin reduces serum calcium and acts as an antagonist to the parathyroid hormone. The human CALC-A/·-C...

Double-blind trials conducted in the early 1980s showed that subcutaneous injections of salmon calcitonin in patients suffering from mania resulted in significant decreases in irritability, euphoria and hyperactivity. Although these results were promising, there were no follow-up studies in this area. A MEDLINE search into the effect of calcitonin on neuronal tissues revealed that calcitonin af...

BACKGROUND Routine measurement of serum calcitonin to detect medullary thyroid carcinoma (MTC) continues to be fiercely debated, although less attention has been paid to the positive predictive value (PPV) of this method. METHODS We collected data from 959 patients with nontoxic nodular goiter; thyroidectomy was performed in 307 of these patients. RESULTS Thirty-nine patients had elevated s...

Established human lymphoid cell lines bound calcitonin with high affinity. Calcitonin binding was detectable on both B cell and T cell lines derived from patients with a spectrum of lymphoproliferative disorders. These cell lines had marked differences in binding capacity per cell even when adjusted for differences in surface area. The binding was linearly related to cell density and showed a c...

osteoporosis, characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enlarged bone fragility and a consequent increase in fracture risk is a leading cause of morbidity and mortality in elderly people. the mortality rate in elderly persons with hip fracture approaches 20%. half of them will be disabled in the remained life. iranian multicenter osteoporosis ...

Administration of pig calcitonin (10 M.R.C. units/kg body wt.) produced an immediate decrease in 5-hydroxytryptamine content in the antrum-duodenum region and ileum. In contrast, the hormone treatment rapidly increased the concentration of 5-hydroxytryptamine in the blood and pancreas. Serum immunoreactive gastrin did not change over a period of 3h after calcitonin administration. The results s...

1. Plasma concentrations of human calcitonin were measured in groups of patients with chronic renal failure, treated either conservatively or by haemodialysis, and compared with a normal group of persons. 2. Plasma calcitonin was statistically significantly elevated in both groups with renal failure. 3. When the data from the three groups were pooled, plasma calcitonin was found to be inversely...

The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP-AST487, a N,N ¶-diphenyl urea with an IC50 of 0.88 Mmol/L on RET kinase, inhibited RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RE...