Chronic infection with Helicobacter pylori, specifically cagA-positive strains, is associated gastric cancer. Thus, measures to prevent H. pylori are required. This study was conducted clarify the prevalence of in community identify source and comprehensively assess risk infection. We collected 90 human faecal samples 73 environmental (water, vegetable, animal samples) from residents an area a ...

Helicobacter pylori is one of the most common pathogens affecting humankind, infecting approximately 50% of the world's population.Of those infected, many will develop asymptomatic gastritis, but 10% develop gastric or duodenal ulcers. The CagA gene is a novel marker for pathogenicity and associated with more severe clinical outcomes and PCR could be rapid and reliable technique to confirm the ...

BACKGROUND AND OBJECTIVES Helicobacter pylori has been strongly associated with peptic ulcer diseases, chronic gastritis, ulcers, and reported as a risk factor for gastric cancer, too. The vaculating cytotoxin (vacA), the cytotoxin associated genes (cagA), the induced by contact with epithelium factor antigen (iceA gene), blood adhesion binding antigen (babA2), and outer membrane protein oipA h...

BACKGROUND To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer. METHODS We evaluated prospectively the prevalence of the infection by more virulent H. pylori strains in 60 relatives of gastric cancer patients comparing the results with those obtained from 49 patients without family h...

AIM To isolate the subtypes of 3' region of cagA gene in Helicobacter pylori (H pylori) strains from Zhejiang Province in China and to investigate their relations to H pylori-associated gastroduodenal diseases. METHODS One hundred and thirty-seven H pylori clinical strains were isolated from the gastric mucosa specimens of 74 patients with chronic gastritis, 61 with peptic ulceration, and 2 w...

AIM The cagA and vacA profiles and their association with clinical findings show a distinct geographical distribution. In the present study, we aimed to determine the cagA status and vacA allelic subtypes in strains isolated from a university hospital in Ankara and to evaluate their associations with histopathological and endoscopic findings. MATERIALS AND METHODS A total of 120 H. pylori str...

background and objectives: alterations in cxcl10 (a th1 chemokine) expression have been associated with various diseases. the aim of this study was to evaluate the serum cxcl10 levels in h. pylori -infected patients with peptic ulcer (pu), h. pylori -infected asymptomatic (as) subjects and healthy h. pylori -negative subjects, and also to determine its association with bacterial virulence facto...

The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil. Also, there was a significant association between isolation of cagA+ s1-type vacA H. pylori in cases of stomach cancer and ulcers as...

Cytotoxin-associated gene A (CagA) diversity with regard to EPIYA-A, -B, -C, or -D phosphorylation motifs may play an important role in Helicobacter pylori pathogenesis, and therefore determination of these motifs in H. pylori clinical isolates can become a useful prognostic tool. We propose a strategy for the accurate determination of CagA EPIYA motifs in clinical strains, based upon one-step ...

BACKGROUND & AIMS The Helicobacter pylori gene cagA and s1 or m1 forms of vacA are more common in disease-associated strains. Recently, forms of cagA encoding multiple type C EPIYA segments (which increase phosphorylation-dependent CagA activity) and a new type i1 "intermediate region" polymorphism in vacA (which confers toxicity) have been described. We assessed the association of new and esta...