BACKGROUND Recent reports suggest that endocrine disruptors may leach into the contents of bottles made from polyethylene terephthalate (PET). PET is the main ingredient in most clear plastic containers used for beverages and condiments worldwide and has previously been generally assumed not to be a source of endocrine disruptors. OBJECTIVE I begin by considering evidence that bottles made fr...

Nuclear receptors play important roles in the maintenance of the endocrine system, regulation of organ differentiation, and fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms. To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying activators of nuclear re...

Historically, reptiles have been used as bioindicators of environmental contaminants and, currently, reptiles have the potential to elucidate the mechanisms of a newly described group of environmental contaminants--endocrine disrupters. Reptiles are particularly good models for studying endocrine altering compounds due to the fact that different species of reptiles have varying modes of gender ...

Abstract Drinking water contains emerging contaminants, i.e., endocrine disrupting compounds (EDCs). However, the extent to which it is publicly viewed as a potential risk that requires attention (public awareness, political obligation, and regulatory efforts) substantially underrated. Thus, this study investigated drinking consumption patterns among consumers of different life stages, evaluate...