Raney MA, Turcotte LP. Evidence for the involvement of CaMKII and AMPK in Ca -dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle. J Appl Physiol 104: 1366–1373, 2008. First published February 28, 2008; doi:10.1152/japplphysiol.01282.2007.—Calcium-calmodulin/dependent protein kinase II (CaMKII), AMP-activated protein kinase (AMPK), and extracellular sign...

affeine, 1,3,7-trimethylxanthine, is among the most frequently inested pharmacologically active subtances in the world. 1 Caffeine can eadily cross the placental barrier to the etus; its clearance is prolonged in pregant women, and its metabolism rate is ow in the fetus because of low levels of nzymes. It may also influence cell deelopment through increasing cellular yclic adenosine monophospha...

AIM The aim of this study was to evaluate the effect of caffeine on collagen biosynthesis in human skin fibroblasts and the influence of hyaluronic acid (HA) on this process. MATERIALS AND METHODS Collagen, [(3)H]-thymidine incorporation, and prolidase activity were measured in confluent human skin fibroblast cultures that had been treated with 1, 2, and 5 mM caffeine and with caffeine and 50...

This study examined the possible effects of caffeine ingestion on muscle metabolism and endurance during brief intense exercise. We tested 14 subjects after they ingested placebo or caffeine (6 mg/kg) with an exercise protocol in which they cycled for 2 min, rested 6 min, cycled 2 min, rested 6 min, and then cycled to voluntary exhaustion. In each exercise the intensity required the subject's m...

OBJECTIVE To assess the role of caffeine restriction in the management of patients with symptomatic idiopathic ventricular premature beats. DESIGN A randomised, double blind, 6 week intervention trial incorporating dietary caffeine restriction, caffeinated coffee, and decaffeinated coffee. SETTING Cardiac outpatient clinic. PATIENTS 13 patients with symptomatic frequent idiopathic ventric...

background: consumption of energy drinks has become widespread among athletes. the effectiveness of red bull and hype energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes was examined in this study. methods: ten male student athletes (age: 22.4 ± 2.1 years, height: 180.8 ± 7.7 cm, weight: 74.2 ± 8.5 kg) performed three randomized maxim...

BACKGROUND Drinking coffee has been linked to reduced calcium conservation, but it is less clear whether it leads to sustained bone mineral loss and if individual predisposition for caffeine metabolism might be important in this context. Therefore, the relation between consumption of coffee and bone mineral density (BMD) at the proximal femur in men and women was studied, taking into account, f...