Melanin plays an important role in protecting the skin against ultraviolet light and is responsible for skin color. However, overproduction of melanin is related to several skin disorders, such as age spots, freckles, café au lait spots, Becker's nevus and other hyperpigmentation syndromes. The aim of this study was to identify the effects of kaempferol-7-O-β-d-glucuronide (K7G) and tilianin, i...

provided the original work is properly cited. CC Type 1 neurofibromatosis, also referred to as von Recklinghausen's disease, is characterized by café-au-lait spots and benign cutaneous neurofibromas and is more common than type 2 neurofibromatosis [1,2]. In contrast, type 2 neurofibromatosis affects the central nervous system (CNS) via spinal cord tumors and bilateral vestibular schwannomas [1-...

BACKGROUND Urticaria pigmentosa (UP) is characterized by dense aggregates of mast cells in the dermis. There is consistent evidence from the literature that mast cells may play a pathogenetic role in the development of neurofibromas and other tumors. OBJECTIVE To study the concomitant appearance of UP with neurofibromas and neurofibroma-like neoplasms. METHODS We analyzed 31,752 records of ...

RATIONALE Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder characterized by cafe au lait macules and neurofibromatosis. Renal artery aneurysms are relatively uncommon. Endovascular techniques are effective in treating renal aneurysms but successful cases are rarely reported in NF-1 adults. PATIENT CONCERNS The patient was one 23-year-old female presented with hypertension, mu...

McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), café-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common...

Case presentation: A 5-year-old girl initially suspected of having neurofibromatosis type 1 (NF1) due to developmental delay and café au lait spots. In March 2022, evolved with neurodevelopmental regression, progressive loss strength gait ataxia. Three months later she had an afebrile epileptic seizure, a computed tomography (CT) scan the brain was performed, which showed leukoencephalopathy mi...