نتایج جستجو برای: c677t

تعداد نتایج: 1675  

Journal: :Brain research bulletin 2006
Ali Sazci Emel Ergul Nese Tuncer Gurler Akpinar Ihsan Kara

Hyperhomocysteinemia is an independent risk factor for ischemic stroke. The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a critical role in modulating the levels of plasma homocysteine. Two polymorphisms in the MTHFR gene, C677T, A1298C result in reduced enzyme activity. The mechanisms of ischemic and hemorrhagic stroke are not well understood. Although controversial, previous studi...

Journal: :BMC Medicine 2004
Rod A Lea Micky Ovcaric James Sundholm John MacMillan Lyn R Griffiths

BACKGROUND The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that may also be affected by genetically influenced hyperhomocysteinaemia. To determine whether the C677T...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Mine S Cicek Nora L Nock Li Li David V Conti Graham Casey John S Witte

Previous reports indicate that polymorphisms in the MTHFR gene play a role in cancer development, but their potential impact on prostate cancer has not been well studied. Here, we evaluate the association between two MTHFR polymorphisms, C677T and A1298C, and prostate cancer risk and aggressiveness in a moderately large family-based case-control study (439 cases and 479 sibling controls). Among...

2016
Guanghui Xu Xingcheng Dong Zhenhuan Li Jian Zhang Xiaodong Liu Lianshun Jia

Purpose: This study was aimed to detect the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T and A1298C) and ankylosing spondylitis (AS) risk. Methods: With matched age and gender, 113 AS patients and 120 healthy controls were recruited in this case-control study. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) were adopted...

2018
Vladimir Kostić

Both methylenetetrahydrofolate (MTHFR) C677T genotype and levodopa treatment may give rise to elevated serum homocysteine levels in parkinsonian patients. We aimed to clarify the interplay of these factors in pathogenesis of Parkinson’s disease (PD)-related hyperhomocysteinemia. Total serum levels of homocysteine (tHcy) and MTHFR C677T genotype were investigated in levodopa-treated and -untreat...

2013
Mohammad Soleiman Soltanpour Zahra Soheili Ali Shakerizadeh Ali Akbar Pourfathollah Shahram Samiei Reza Meshkani Mohammad Shahjahani Abbas Karimi

BACKGROUND Elevated plasma homocysteine (Hcy) level has been established as a significant risk factor for venous thrombosis and cardiovascular disease. Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated with elevated plasma Hcy concentration and may contribute to retinal vein thrombosis (RVT) development. The aim of the present study was to inves...

2015
Lin Yun Rui Xu Guohua Li Yucai Yao Jiamin Li Dehong Cong Xingshun Xu Lihua Zhang

The combined hyperhomocysteinemia condition is a feature of the Chinese hypertensive population. This study used the case-control method to investigate the association between plasma homocysteine and the C677T gene polymorphism of its key metabolic enzyme, 5, 10-methylenetetrahydrofolate reductase (MTHFR), and early renal damage in a hypertensive Chinese Han population.A total of 379 adult esse...

Journal: :Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 2017
Adriana de Góes Soligo Ricardo Barini Joyce Maria Annichino-Bizzacchi

Introduction The importance of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in infertile women remains controversial. Objective To evaluate if the MTHFR C677T mutations are more frequent in infertile women, and if they can be associated with the occurrence of infertility in the Brazilian population. Methods This case-control study included 130 infertile women consu...

Journal: :Schizophrenia research 2007
Joshua L Roffman Anthony P Weiss Thilo Deckersbach Oliver Freudenreich David C Henderson Shaun Purcell Donna H Wong Charles H Halsted Donald C Goff

BACKGROUND The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been associated with both overall schizophrenia risk and severity of negative symptoms. This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this rel...

Journal: :Journal of Ayub Medical College, Abbottabad : JAMC 2010
Faraz Ahmed Bokhari Tania A Shakoori Syed Ahmad A Hassan Hamid J Qureshi Ghulam A Qureshi

BACKGROUND Few studies have studied the role of homocysteine in migraineurs and have produced conflicting results. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples. We assessed the association of the MTHFR C677T variant with migraine, the corresponding homocysteine levels and their correlation. METHOD We studied 27 random adult migraine...

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