Autophagy has been shown to be protective against drug and alcohol-induced liver injury. CYP2E1 plays a role in the toxicity of ethanol, carcinogens and certain drugs. Inhibition of autophagy increased ethanol-toxicity and accumulation of fat in wild type and CYP2E1 knockin mice but not in CYP2E1 knockout mice as well as in HepG2 cells expressing CYP2E1 (E47 cells) but not HepG2 cells lacking C...

A major concern of the Rwandan government and other dairy stakeholders is safety quality milk that goes through informal delivery systems until it gets to consumers. Although introduced best practices scheme stipulates standards for proper handling raw milk, consumers' willingness pay (WTP) such has not yet been assessed. It also unclear whether consumers are aware and/or value safety- quality-...

The stratum corneum (SC) matrix is composed of free fatty acids, cholesterol and ceramides (CERs), which play a key role in the skin barrier function. effect glycerol/petrolatum-based emollient (G/P-emollient) cream on lipid profile SC reconstructed human epithelial (RHE) model was measured. spatial organization intercellular studied using X-ray diffraction. inter-bilayer distance multi-lamella...

Abstract The study was conducted to investigate the feasibility of sodium aluminate activation nonferrous waste foundry sand. aim solidify sand via geopolymerisation into useful civil engineering materials. Green mixed with make a paste which filled 50 × mm 3 mold. mixture cured in an oven for 5 days. concentration aluminate, granulated blast furnace slag (GBFS) : (WFS) ratio, liquid solid rati...

Estimation of the temperature dependence of natural feldspar weathering in two catchments at different elevations yields an apparent Arrhenius activation energy of 18.4 kcal/mol (77.0 kj/mol), much higher than most laboratory values. This finding supports recent suggestions that hydrolytic weathering of silicate minerals may consume carbonic acid and thereby remove atmospheric carbon dioxide mo...

The mining industry generates large quantities of waste as tailings. tailings have an adverse environmental impact. This study explored the utilization and stabilization Barberton gold mine (GMTs) basic oxygen furnace slag (BOFS) to synthesize geopolymers for other applications. geochemical, chemical, geotechnical properties GMT, BOFS, GMT geopolymer, GMT: BOFS geopolymer were also studied. Sod...

Aim. The study is aimed at investigating the incidence of lung cancer (LC) population level with analysis key analytical indicators in context coronavirus. Materials and methods. We have used data from IARC, statistical reference books P.A. Herzen Moscow Research Oncological Institute, N.N. Petrov NMRC Oncology, database Population Cancer Registry St. Petersburg (DB PСR Petersburg) for current ...