OBJECTIVE The role of mitochondrial function in the complex pathogenesis of type 2 diabetes is not yet completely understood. Therefore, the aim of this study was to investigate serum concentrations of short-, medium- and long-chain acylcarnitines as markers of mitochondrial function in volunteers with normal, impaired or diabetic glucose control. METHODS Based on a 75 g oral glucose toleranc...

In this note we study the conditions under which leading models for underreported counts are identified. In particular, we highlight a peculiar identification problem that afflicts two of the most popular models in this class. JEL classification code: C13, C25.

Although considerable research has been conducted in recent years on the mechanisms of fatty acid synthesis and oxidation in animal tissues (1) and in microorganisms (2), no similar studies of higher plants have yet been reported, despite the great importance of fat-storing seeds and fruits in the economy of nature and the value to comparative biochemistry of an understanding of fatty acid biog...

The microstructures of two metal hydride (MH) alloys, a Zr7Ni10 based Ti15Zr26Ni59 and a C14 Laves phase based Ti12Zr21.5V10Ni36.2Cr4.5Mn13.6Sn0.3Co2.0Al0.4, were studied using the electron backscatter diffraction (EBSD) technique. The first alloy was found to be composed of completely aligned Zr7Ni10 grains with a ZrO2 secondary phase randomly scattered throughout and a C15 secondary phase pre...

AIM Cationic ethylphosphatidylcholines (ePCs) were evaluated for the delivery of siRNA in modified breast cancer cells. MATERIALS AND METHODS Dimyristoleoyl-ePC (C14), dioleoyl-ePC (C18), and dilauroyl-ePC (C12) nanoparticles were complexed with siRNA for green fluorescent protein (GFP) suppression in modified MCF-7 breast cancer cells. The kinetics of GFP suppression were followed over the c...

Weinhouse and co-workers (39-43) have estab lished that the Krebs tricarboxylic acid cycle operates in a variety of experimental tumors and that fatty acid oxidation, believed to be non existent in tumors (9), provides 2-carbon frag ments for continuous operation of this cycle in neoplastic tissues. Our studies with the mouse hepatoma C954, carried by mice of the C57-Leaden strain, also led us ...

We study spherically symmetric spacetimes in Einstein-aether theory three different coordinate systems, the isotropic, Painlevè-Gullstrand, and Schwarzschild coordinates, which aether is always comoving, present both time-dependent time-independent exact vacuum solutions. In particular, isotropic coordinates we find a class of static solutions characterized by single parameter c14 closed forms,...

Background: Diseases caused by microorganisms of the genus Mycobacterium continue to be a serious problem. The cell envelope constitutes up to 60% of the dry weight of lipids. The cell wall of the mycobacterium is essential for their growth and survival in the infected host. The cell wall lipids have been isolated from M. bovis BCG and M. kansasii mycobacterial strains and studied the incorpora...

The biosynthesis of eukaryotic lipid-linked oligosaccharides (LLOs) that act as donor substrates in eukaryotic protein N-glycosylation starts on the cytoplasmic side of the endoplasmic reticulum and includes the sequential addition of five mannose units to dolichol-pyrophosphate-GlcNAc2. These reactions are catalyzed by the Alg1, Alg2 and Alg11 gene products and yield Dol-PP-GlcNAc2Man5, an LLO...

Pneumolysin is the one of the major virulence factor of the bacterium Streptococcus pneumoniae. In previous report, it is shown that β-sitosterol, a natural compound without antimicrobial activity, is a potent antagonist of pneumolysin. Here, two new pneumolysin natural compound inhibitors, with differential activity, were discovered via haemolysis assay. To explore the key factor of the confor...