نتایج جستجو برای: c2 gene

تعداد نتایج: 1158142  

G.R. Habibi K. Esmaeil Nia N. Bordbar R. Hashemi-Fesharki S. Bozorgi

  The sporozoites of Theileria annulata invade bovine MHC II cells, where they differentiate into schizonts. The later can immortalize and induce fundamental changes in their host cells. Live attenuated vaccine is an important way of controlling T. annulata infection of cattle. Production is by prolonged cultivation of macroschizont-infected cells. The mechanisms underlying this transformation ...

Journal: :Genetics 1977
R S Holmes

Electrophoretic polymorphisms for stomach alcohol dehydrogenase (ADH-C2) and kidney L-alpha-hydroxyacid oxidase (HAOX-B4) have been identified in an Asian subspecies of mouse, Musmusculus castaneous. These variants are inherited in a normal Mendelian fashion with two alleles in each case showing codominant expression. The structural gene loci for those enzymes (Adh-3 and Hao-2, respectively) ar...

Journal: :The Journal of biological chemistry 2002
Tatyana Sklyarova Veerle De Corte Kris Meerschaert Liesbeth Devriendt Berlinda Vanloo Juliet Bailey Lynnette J Cook Mark Goethals Jozef Van Damme Magda Puype Joel Vandekerckhove Jan Gettemans

We report the isolation of a cDNA clone encoding a 60-kDa protein termed fragmin60 that cross-reacts with fragmin antibodies. Unlike other gelsolin-related proteins, fragmin60 contains a unique N-terminal domain that shows similarity with C2 domains of aczonin, protein kinase C, and synaptotagmins. The fragmin60 C2 domain binds three calcium ions, one with nanomolar affinity and two with microm...

Journal: :International Journal of Chronic Obstructive Pulmonary Disease 2021

Purpose This study aimed to identify the COPD molecular subtypes reflecting pulmonary function damage on basis of metabolism-related gene expression, which provided opportunity metabolic heterogeneity and association pathways with damage. Methods Univariate linear regression Boruta algorithm were used select genes associated forced expiratory volume in first second (FEV1) FEV1/forced vital capa...

Abbas Samadi, Mohammad H Hedayati,

Apolipoprotein E (apo E) is a structural constituent of several serum lipoprotein classes. It plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein (LDL) and chylomicron remnant receptors. Three common alleles called e2, e3 and e4 have been described, which code for three protein isoforms (E2, E3 and E4). The polymorphism is clinically significant, and it...

Journal: :The Journal of biological chemistry 1990
R Gahlmann L Kedes

The gene encoding human fast skeletal muscle troponin C (TnC) was cloned, mapped, and sequenced. The locations of intron positions in this gene were compared to those in the related genes for mouse slow skeletal TnC and vertebrate and nonvertebrate calmodulins. We detected strikingly similar purine-rich DNA sequences on the coding strand in the basal promoter of the genes for fast and slow trop...

Journal: :Journal of current biomedical research 2023

The seed extracts of Nigella sativa (black cumin) have been used in different civilizations around the world for centuries to treat various animal and human ailments. C. albicans is a member normal microbiome, but under certain circumstances it can cause infections that range from superficial skin life-threatening systemic infections. Resistance antifungal drugs has on increase recent years. Se...

Journal: :The Journal of biological chemistry 1998
P R Taylor J T Nash E Theodoridis A E Bygrave M J Walport M Botto

Factor B is a serine protease, essential for the function of the alternative pathway of complement activation. To study further the importance of the alternative pathway of complement activation in vivo and to help elucidate any additional functions of factor B or its activation fragments we developed, by homologous recombination in embryonic stem cells, mice with a disrupted factor B gene. Fac...

Journal: :Clinical and translational discovery 2023

Purpose Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous complex malignancies. The present study aimed to explore potential molecular classifications establish promising prognostic candidate biomarkers for human papillomavirus (HPV)-negative HNSCC. Methods We performed unsupervised clustering in HPV-negative patients from the TCGA-HNSCC database identified subclusters based on ...

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