intramascular (im) administration of apomorphine (a mixed d1/d2 dopamine receptors agonist 0.2-1.6 mg/kg) induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. in this study the effect of lithium (li+, 240 mg/kg, im) and ami-193 (a new 5-ht2 antagonist, 0.003 mg/pigeon) on apomorphine-induced peking (aip) were investigated. this study showed that li+ and ami-193 did not...

ABSTRACT The C-terminal of G protein-coupled receptors is now recognized as being important for protein activation and signaling function. To detect the role tail in receptor activation, we used α1b-AR, which has a long 164 amino acids. We constructed intramolecular FRET sensors, was truncated to 10 (∆C-10), 20 (∆C-20), 30 (∆C-30), 50 (∆C-50), 70 (∆C-70), or 90 (∆C-90). mutants ∆C-10, ∆C-20, ∆C...

These experiments were designed to evaluate the role of macrophage plasma membrane receptors for the third component of complement (C) and for the Fc portion of IgG in the ingestion phase of phagocytosis. Sheep erythrocyte (E) were coated with anti-E IgG [E(IgG)]; these E(IgG) were then attached to cultivated monolayers of mouse peritoneal macrophages under conditions which reversibly inhibit i...

The epigenetics of methylated and unmethylated DCR1 DCR2 (decoy receptors 1 2) are genes encoding membrane that can bind to TRAIL causing inhibition in the apoptotic pathway. Epigenetic detection was developed as a biomarker breast cancer. One methods is using PCR. most important step PCR process determination annealing temperature. This research performs Tm analysis insilico program from Neb, ...

toll-like receptor 4 (tlr4), considered one of  the most important tlr, recognizes lipopolysaccharide of  gram-negative bacteria. recognition  of  ligands by  tlrs  induces signaling pathways resulting in activation of transcriptional factors such as nf-κb which are involved in  the  expression of  inflammatory cytokines and  chemokines. to  prevent  an inappropriate immune response, a complex ...