In the multinucleate fungus Ashbya gossypii, cytoplasmic microtubules (cMTs) emerge from the spindle pole body outer plaque (OP) in perpendicular and tangential directions. To elucidate the role of cMTs in forward/backward movements (oscillations) and bypassing of nuclei, we constructed mutants potentially affecting cMT nucleation or stability. Hyphae lacking the OP components AgSpc72, AgNud1, ...

Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies to coagulation FVIII. Bleeding episodes at presentation are spontaneous and severe in most cases. Optimal hemostatic therapy is controversial, and available data are from observational and retrospective studies only. The EACH2 registry, a multicenter, pan-European, Web-based database, reports current patient management. ...

The development of inhibitory antibodies to factor VIII is a serious complication of hemophilia. FEIBA (factor VIII inhibitor-bypassing activity), an activated prothrombin complex concentrate (aPCC), and NovoSeven, recombinant factor VIIa (rFVIIa), are used as hemostatic bypassing agents in treating patients with inhibitors. The FENOC study was designed to test equivalence of the products in th...

In the design of embedded systems, hardware and software need to be co-explored together to meet targets of performance and energy. With the use of application-specific instruction-set processors, as a stand-alone solution or as a part of a system on chip, the customization of processors for a particular application is a known method to reduce energy requirements and provide performance. In par...

BACKGROUND Child delivery in a health facility is important to reduce maternal mortality. Bypassing nearby birthing facility to deliver at a hospital is common in developing countries including Nepal. Very little is known about the extent and determinants of bypassing the birthing centres in Nepal. This study measures the status of bypassing, characteristics of bypassers and their reasons for b...

Introduction Acquired haemophilia A (AHA) is a rare but clinically relevant bleeding disorder due to autoantibodies (inhibitors) against coagulation factor VIII (FVIII)1-3. AHA is usually triggered by infections, malignancies, autoimmune diseases, or pregnancy. Some cases associated with drug intake have also been described, but about half of cases remain unexplained and are classified as "idio...

We present an extension of access-based localization technique to mitigate a substantial inefficiency in handling procedure calls. Recently, access-based localization was proposed as an effective way of tightly localizing abstract memories. However, it has a limitation in handling procedure calls: the localized input memory for a procedure contains not only memory locations accessed by the proc...

The purpose of the switch feature is to prevent distortion of high signal levels in receiver applications by bypassing the amplifier altogether. The bypass switch can be thought of as a 1-bit digital AGC circuit that not only prevents distortion by bypassing the MGA-72543 amplifier, but also Figure 1. MGA-72543 Functional diagram. reduces front-end system gain by approximately 16 dB to avoid ov...

Abs t rac t . A novel anaphase block phenotype was found in fission yeast temperature-sensitive cut9 mutants. Cells enter mitosis with chromosome condensation and short spindle formation, then block anaphase, but continue to progress into postanaphase events such as degradation of the spindle, reformation of the postanaphase cytoplasmic microtubule arrays, septation, and cytokinesis. The cut9 m...