The title mol-ecule, C(21)H(26)O(3), has a six-membered planar carbon ring as the central core, substituted at position 1 with phen-oxy-carbonyl, at position 2 with hy-droxy and at positions 3 and 5 with tert-butyl groups. The structure shows two independent but very similar mol-ecules within the asymmetric unit. For both independent mol-ecules, the ester carboxyl-ate group is coplanar with the...

Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured Plasmodium falciparum is highly variable depending on the commercial source. Here we identify a minor contaminant (pepstatin butyl ester) as the active anti-parasitic principle. We synthesize a series of derivatives and characterize an anal...

Novel benzamide derivatives (19-24, 32a-c, 43d-f), each possessing a cycloaminoalkanecarboxylic acid side chain, were synthesized and their gastrointestinal prokinetic and dopamine D2 receptor antagonist activities were evaluated. 4-[(4-Amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetic acid (19) exhibited the most potent gastro- and colon-prokinetic activities, through intravenous admin...

S. Gomathi and K.M. Subbu Rathinam* ABSTRACT To identify the insecticidal components of Saraca asoca bark were evaluated by standard protocol using the equipment Perkin-Elmer Gas Chromatography–Mass Spectrometry. The mass spectrum of the compounds found in the extract was matched with the National Institute of Standards and Technology (NIST) library. The GC-MS analysis revealed the presence of ...

In this study, a quantitative method for the content determination of rutin, 5-O-coumaroylquinic acid methyl ester, chlorogenic butyl and kaempferol in Amygdalus persica L. flowers during different harvest periods was established to investigate its various rules determine optimal harvesting period. The performed on XTERRA MS C18 column with mobile phase consisting 0.1% formic aqueous solution a...

Five phthalate ester and related compounds (phthalic anhydride, phthalamide, di(2-ethylhexyl) phthalate, di(2-ethylhexyl) adipate and butyl benzyl phthalate) have been tested for carcinogenic effects in standard lifetime rodent feeding studies. Groups of 50 male and female rats and mice were fed diets containing various concentrations of the test chemicals for 102-106 consecutive weeks. The die...

The motional restrictions of the proline pyrrolidine ring allow this secondary amine amino acid to act as a turn inducer in many peptides and proteins. The pyrrolidine ring is known to exhibit two predominant pucker modes (i.e., C-4 (Cgamma) exo and endo envelope conformers whose ratio can be controlled by proper substituents in the ring). In nature, the exo puckered 4(R)-hydroxy-l-proline play...

Antifriction synergies between an ionic liquid (IL) and nanopowders as additives of ester base oil were analysed at rolling conditions. For this aim, two nanodispersions based on hybrid combinations hexagonal boron nitride nanoparticles (h-BN) or graphene nanoplatelets (GnP) with tri(butyl) ethylphosphonium diethylphosphate in triisotridecyltrimellitate (TTM) the mixture TTM IL using tribometer...

BACKGROUND Fatty acids occur in nearly all living organisms as the important predominant constituents of lipids. While all fatty acids have essentially the same chemical nature, they are an extremely diverse group of compounds. MATERIALS AND METHODS To test the hypothesis, fatty acids of alkaliphiles isolates, Bacillus subtilis SVUNM4, Bacillus licheniformis SVUNM8, Bacillus methylotrohicus S...