نتایج جستجو برای: burkholderia mallei
تعداد نتایج: 5991 فیلتر نتایج به سال:
Burkholderia pseudomallei and B. mallei are bacterial pathogens that cause melioidosis and glanders, whereas their close relative B. thailandensis is non-pathogenic. All use the trimeric autotransporter BimA to facilitate actin-based motility, host cell fusion, and dissemination. Here, we show that BimA orthologs mimic different host actin-polymerizing proteins. B. thailandensis BimA activates ...
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility ge...
glanders, caused by infection with the bacterium burkholderia mallei is a highly contagious and often fatal zoonotic disease of solipeds. it is an old disease, described as early as 400 bc by hippocrates and 330 bc by aristotlein the past, b. mallei was an important equine pathogen worldwide. its spread was facilitated by the use and transport of horses, especially when animals were housed unde...
Burkholderia mallei is a gram-negative bacterium which causes the potentially fatal disease glanders in humans; however, there is little information concerning cell-mediated immunity to this pathogen. The role of gamma interferon (IFN-gamma) during B. mallei infection was investigated using a disease model in which infected BALB/c mice normally die between 40 and 60 days postinfection. IFN-gamm...
Glanders caused by Burkholderia mallei infected mainly the Equidae and it is really fatal zoonosis. It was known since ancient times. The horses, mules, donkeys can get infection skin abrasion, during direct contact between animals or with water instruments, also bacterium be found in soil. Since disease eradicated from most of developed world, endemic several countries surrounding Iraq other r...
Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase
Yersinia pestis is a gram negative zoonotic pathogen responsible for causing bubonic and pneumonic plague in humans. The pathogen uses a type III secretion system (T3SS) to deliver virulence factors directly from bacterium into host mammalian cells. The system contains a single ATPase, YscN, necessary for delivery of virulence factors. In this work, we show that deletion of the catalytic domain...
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