In this work the enhancing effect of cyclodextrins on the buccal permeation of a hydrophobic model drug, omeprazole was studied. First, the influence of the complexation with cyclodextrins in the absence and in the presence of an alkali agent, L-arginine, on the drug stability was checked at neutral conditions since omeprazole alone is only stable in basic conditions. In vitro transbuccal perme...

The antigenic substrate of the antiperinuclear factor (APF) in human buccal mucosa cells was studied by light microscopy, cytochemistry, and the immunofluorescence technique (IFT). The cytoplasmic granules against which the APF is directed stained basophilic in light-microscopical staining techniques. The granules did not show a positive reaction product by techniques in which special chemical ...

Primary squamous cell carcinoma of head and neck usually metastasizes to the regional lymph node, lung, and bone. Ophthalmic metastasis in squamous cell carcinoma of head and neck is uncommon. Most of the ophthalmic metastasis is due to the carcinoma of the breast and lung. Squamous cell carcinoma of the oral cavity with metastasis to the eye has not yet been documented. We are presenting herew...

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrie...

The objective of the paper is to study the effect of a permeation enhancer, sodium taurocholate on permeation of Ondansetron HCl from bioadhesive buccal tablet formulation by performing ex-vivo permeation experiments using porcine buccal mucosa. Optimized formulation has selected based on in-vitro drug release studies of bilayered bioadhesive buccal tablets. To the optimized formulation, 10mM s...

BACKGROUND We report our results after 100 urethroplasties for the treatment of urethral stricture both at the bulbar and penile urethra, using different techniques. METHODS 100 patients with the diagnosis of anterior urethral stricture, that were submitted for urethroplasty in the period 1997-2007. Of them, 57 treated by end to end urethroplasty. 4 patients underwent augmented free graft ana...

Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...

Cellular angiofibroma (CA) is an uncommon benign soft tissue tumor and typically arises in genitourinary region. There are only three reported cases at the head neck region to best of our knowledge; two different sites eyelid buccal mucosa.