Purpose: To formulate Eudragit RS 100-based nanoparticles containing metronidazole (MTZ NPs) and incorporate them into hydrogels using different gelling agents for controlled release in the buccal mucosa.
 Method: MTZ NPs were fabricated nanoprecipitation method. (1 % w/w) introduced excipients. Physicochemical properties of NPs, mucoadhesive strength spreadability hydrogels, ex vivo perme...

Enalapril maleate is used in the treatment of hypertension and angina pectoris. It shows low bioavailability due to high hepatic first pass metabolism. Hence the present work was undertaken to formulate mucoadhesive buccal films of enalapril maleate with an objective to improve therapeutic efficacy, patient compliance and the bioavailability. In the present study ten formulations of mucoadhesiv...

Buccal films were prepared from aqueous and ethanolic Metolose gels using the solvent casting approach (40°C). The hydration (PBS and simulated saliva), mucoadhesion, physical stability (20°C, 40°C), in vitro drug (omeprazole) dissolution (PBS and simulated saliva), ex vivo permeation (pig buccal mucosa) in the presence of simulated saliva, ex vivo bioadhesion and cell viability using MTT of fi...

terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...

Medicated chewing gums are defined by the European Pharmacopoeia 1 and the guidelines for pharmaceutical dosage forms as „„solid single dose preparations with a base consisting mainly of gum that are intended to be chewed but not swallowed, providing a slow steady release of the medicine contained‟‟2. It can be either used for local treatment of mouth disease or systemic delivery by direct intr...

A major challenge in oral drug delivery is the development of novel dosage forms to promote absorption of poorly permeable drugs across the intestinal epithelium. To date, no absorption promoter has been approved in a formulation specifically designed for oral delivery of Class III molecules. Promoters that are designated safe for human consumption have been licensed for use in a recently appro...

Liquid crystalline systems of glyceryl monooleate/water are used as drug delivery due to their complex structure that controls diffusion. Mucoadhesive properties monooleate suggest it can be for buccal delivery. Using additives is a strategy modify physical and chemical liquid optimize performance system. However, the presence significantly alter such phase behavior, swelling mucoadhesion. Our ...

Most common methods of delivery include the preferred topical (skin), transmucosal (nasal, buccal, sublingual, vaginal, ocular and rectal) inhalation routes. The conventional dosage forms provide drug release immediately it causes fluctuation level in blood depending upon form. Therefore to maintain concentration within therapeutically effective range needs novel system. In past few decades, co...

In this study, buccal mucoadhesive tablets of meloxicam were formulated for drug delivery as an alternative route. Direct compression method was applied for the preparation of tablets. Also, different polymers, including hydroxypropyl methyl cellulose (HPMC) 1000, 4000, and 10000, as well as carbopol 934p and carbopol 971p were used as the mucoadhesive polymer and retardant polymer. Thirteen fo...

The buccal region of oral cavity is an attractive site for administration of drug of choice. Buccal route is an excellent for systemic delivery of drug providing great bioavailability. A significant reduction in dose and dosing frequency can be achieved, thereby reducing dose dependent side effects, patient compliance and prolonging duration of action.Buccal dosage form increase bioavailability...