BTD, Ltd. has introduced a new direction in the use of antisense agents in therapeutics that can lead to breakthroughs in the development of antisense drugs. As described in this non confidential summary, it has already resulted in the development of promising antisense antiviral agents, as demonstrated by their significant in vitro effects on hepatitis C virus activity as well as on other viru...

A new heteroarylene-vinylene donor-acceptor low bandgap polymer, the poly(DEHT-V-BTD), containing vinylene-spaced efficient donor (dialkoxythiophene) and acceptor (benzothiadiazole) moieties, is presented. Electropolymerization has been carried out by several electrochemical techniques and the results are compared. In particular, the pulsed potentiostatic method was able to provide layers with ...

It was shown that constraint satisfaction problems (CSPs) with a low width can be solved effectively by structural methods. In particular, the BTD method which exploits the concepts of goods and nogoods makes it possible to solve efficiently difficult instances. However, the memory space required for the storage of these (no)goods may make difficult or impossible the resolution of certain probl...

Pseudorhabdosynochus seabassi sp. n. (Monogenea: Diplectanidae) from the gill filaments of Lates calcarifer Bloch, a marine teleost fish held in floating sea cages in Guangdong Province, China, is described based on morphological observations and molecular data. The shapes of the male copulatory organs (MCO) of Pseudorhabdosynochus spp. were the focus of this study. The typical proximal part of...

This research verified whether the practices of corporate social responsibility (CSR) and tax aggressiveness are complementary, substitute or unrelated. A total 1,081 observations from Brazilian companies listed on B3 were analyzed between 2010 2017. The survey used guidelines Global Reporting Initiative (GRI) to measure degree CSR. results show a substitution relationship with high GRI when me...

The purpose of this study was to determine the effect book tax differences and company financial performance on profit growth, in companies with largest market capitalization Indonesia from 2016 2020. This uses quantitative data types descriptive analysis test methods multiple linear regression analysis. sampling method is done by purposive technique. results showed that simultaneously (BTD), a...

The so-called block-term decomposition (BTD) tensor model, especially in its rank-(Lr,Lr,1) version, has been recently receiving increasing attention due to enhanced ability represent systems and signals that are composed of block components rank higher than one, a scenario encountered numerous diverse applications. Its uniqueness approximation have thus thoroughly studied. challenging problem ...

Biotin in breakdown products of biotinylated carboxylases serves as substrate for biotinylation of histones by biotinidase. Here we determined whether biotinylation of histones might play a role in repair of damaged DNA and in apoptosis. Jurkat cells were exposed to UV light to induce DNA damage. Abundance of thymine dimers increased about three times in response to UV exposure, consistent with...

Bouvardia ternifolia (Cav.) Schltdl. is a shrub that belongs to the Rubiaceae family and distributed throughout México; it has been used for its antioxidant, neuroprotective, anti-inflammatory properties. This work aimed evaluate protective effects of B. root extracts on blood-brain barrier positive regulation cytokines IL-1β, IL-6, TNF-α, characterization compounds present in dichloromethane (...

Abstract A combined algorithm comprising multiple dust detection methods was developed using infrared (IR) channels onboard the GEOstationary Korea Multi-Purpose SATellite 2A equipped with Advanced Meteorological Imager (GK2A/AMI). Six cloud tests brightness temperature difference (BTD) were utilized to reduce errors caused by clouds. For detecting storms, three standard BTD (i.e., $${BT}_{12.3...