نتایج جستجو برای: bruton
تعداد نتایج: 389 فیلتر نتایج به سال:
X-linked agammaglobulinemia (XLA) or Bruton’s disease is a rare genetic disorder, discovered in 1952, that mitigates the immune response to infections1. Early studies have associated mutations in the Bruton tyrosine kinase (BTK) gene (GDB 120542) with XLA development2,3. The BTK gene, spanning 37.5 kilobases (kb) with 19 exons, is located on the X chromosome at Xq21.3–Xq22 and encodes Bruton ag...
Ibrutinib (Imbruvica), a small-drug inhibitor of Bruton tyrosine kinase (BTK), is currently undergoing clinical testing in patients with multiple myeloma, yet important questions on the role of BTK in myeloma biology and treatment are outstanding. Using flow-sorted side population cells from human myeloma cell lines and multiple myeloma primary samples as surrogate for the elusive multiple myel...
INTRODUCTION The aim was to determine the effect of the Bruton tyrosine kinase (Btk)-selective inhibitor PCI-32765, currently in Phase I/II studies in lymphoma trials, in arthritis and immune-complex (IC) based animal models and describe the underlying cellular mechanisms. METHODS PCI-32765 was administered in a series of murine IC disease models including collagen-induced arthritis (CIA), co...
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