Background: Brucellosis, a zoonosis caused by four species of brucella, has a high morbidity. The major cause of brucellosis worldwide is brucella melitensis. Medicinal plants are considered as new antibacterial sources that could replace conventional antibiotics in the treatment of antibiotic-resistant bacteria. The aim of this study was to evaluate the efficacy of some native plants, alone an...

Brucellosis is a highly contagious zoonosis caused by Brucella. Brucella can invade and persist inside host cells, which results in chronic infection. We constructed AIR interference and overexpression lentiviruses to acquire AIR interference, overexpression, and rescue stable expression cell lines. We also established a Brucella melitensis 16M-infected macrophage model, which was treated with ...

Brucella spp. cause chronic zoonotic disease often affecting individuals and animals in impoverished economic or public health conditions; however, these bacteria do not have obvious virulence factors. Restriction of iron availability to pathogens is an effective strategy of host defense. For brucellae, virulence depends on the ability to survive and replicate within the host cell where iron is...

The effect of polyadenylic acid: polyuridylic acid complex (poly A: U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 ,ug of poly A:U to vaccines rendered 3 X 108 B. melitensis cells in saline as immunogenic as 3 X 10"1 cells in oil adjuvant against a severe B. abortus challenge. In the mouse...

Antibiotic sensitivities for Linezolid of 20 strains that reported as Brucella melitensis in blood cultures between 2014 and 2016 were evaluated by disc diffusion and E-test methods. According to the disc diffusion method results, 20 Brucella melitensis strains had ≥ 25 mm of antibiotic sensitivity zones. Etest measurements revealed that MIC values were between 1.5 and 6 μg. Linezolid can be an...

brucellosis is a zoonotic disease transmitted to humans either from animals or from their products.although brucellosis can be found worldwide, the mediterranean basin, south and central america, easterneurope, asia, africa, the caribbean, and the middle east have currently been listed as high-risk regions. thegenus brucella is classified in at least nine species. brucella melitensis is the glo...

brucella melitensis and brucella abortus are of the most important causes of brucellosis, an infectious disease which is transmitted either directly or indirectly including consuming unpasteurized dairy products. both strains are considered endemic in iran. common diagnostic methods such as bacteriologic cultures are difficult and time consuming regarding the bacteria. the aim of this study was...

Brucellosis is a zoonotic disease that can cause severe illness in humans and considerable economic loss in the livestock industry. Although small ruminants are the preferential host for Brucella melitensis, this pathogen has emerged as a cause for Brucella outbreaks in cattle. S19 vaccination is implemented in many countries where B. abortus is endemic but its effectiveness against B. melitens...

The authors describe an attempt to control Brucella melitensis infection in a large camel herd in Saudi Arabia. Sera from the entire herd (2,536) were examined by the Rose Bengal and standard United States of America buffered plate agglutination tests. The overall Brucella seroprevalence was 8%. Milk samples from the 120 seropositive milking camels were cultured on Brucella-selective media. B. ...