We evaluated bronchial responsiveness to inhaled albuterol (salbutamol), ipratropium bromide, methacholine, and propranolol in eight heart-lung transplant (HLT) recipients 2.3 +/- 1.5 months (mean +/- SD) (range, 1 to 4.5 months) after HLT. All patients had a restrictive ventilatory defect but none had airflow limitation (FEV1/FVC = 0.93 +/- 0.05) (range, 0.86 to 0.97). Specific airway conducta...

BACKGROUND Epidemiological research into the role of traffic pollution on chronic respiratory and allergic disease has focused primarily on children. Studies in adults, in particular those based on objective outcomes such as bronchial hyperresponsiveness, skin sensitisation, and lung function, are limited. METHODS We have used an existing cohort of 2644 adults aged 18-70 living in Nottingham,...

Cigarette smoking is a risk factor for the development of airway hyperresponsiveness and chronic obstructive pulmonary disease. Little is known concerning the effect of cigarette smoking on the contractility of airway smooth muscle. The current study was performed to determine the responsiveness of bronchial smooth muscles isolated from rats that were subacutely exposed to mainstream cigarette ...

Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, but is also frequently demonstrated by children and adults with chronic obstructive lung diseases. AHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in children with post-infectious bronchiolitis obliterans (BO). Meth...

Immunol 2010; 126: 527–534. 4 Currie GP, Jackson CM, Lee DK, et al. Determinants of airway hyperresponsiveness in mild asthma. Ann Allergy Asthma Immunol 2003; 90: 560–563. 5 Riemersma RA, Postma DS, Van der Molen T. Budesonide/ formoterol maintenance and reliever therapy in primary care asthma management: effects on bronchial hyperresponsiveness and asthma control. Prim Care Respir J 2012; 21:...

Recommendations for the standardisation of bronchial challenge were made in 1985, and updated in 1993. However, neither document recommended a single protocol or even criteria that would recommend the adoption of a particular method. Even the terminology lacks uniformity, bronchial responsiveness being used in this review in the hope that it oVends the fewest number of readers. Distinction has ...

Bronchial hyperresponsiveness and eosinophilia are major characteristics of asthma. Calcitonin gene-related peptide (CGRP) is a neuropeptide that has various biological actions. In the present study, we questioned whether CGRP might have pathophysiological roles in airway hyperresponsiveness and eosinophilia in asthma. To determine the exact roles of endogenous CGRP in vivo, we chose to study a...

bronchial hyperresponsiveness using methacholine and adenosine monophosphate: relationship to asthma severity and (2)-receptor genotype. Am J Respir Crit Care Med 2000; 162:1318–1322 8 Koskela HO, Hyvärinen L, Brannan JD, et al. Responsiveness to three bronchial provocation tests in patients with asthma. Chest 2003; 124:2171–2177 9 Hunter CJ, Brightling CE, Woltmann G, et al. A comparison of th...

BACKGROUND Cough is an important symptom of patients with chronic obstructive pulmonary disease (COPD). The cough threshold to citric acid and capsaicin in patients with COPD and in normal volunteers was measured, as well as bronchial hyperresponsiveness to methacholine. METHODS Nineteen patients with COPD and 22 controls were recruited. Subjects underwent a methacholine bronchoprovocation te...