This is the first scientific report of hereditary hemorrhagic telangiectasia (HHT) epistaxis treatment by intranasal spraying of the vascular endothelial growth factor (VEGF) inhibitor bevacizumab (Avastin). Epistaxis in patients with HHT is a morbid, mortal condition that is difficult and unpleasant to manage. Nasal telangiectasia growth is modulated by VEGF, which is elevated in HHT patients....

A rare case of splenic harmartoma in a 31 year old female is reported. She was admitted with splenomegaly, fever and chronic history of epistaxis. Routine hematological survey revealed pancytopenia and mild hypercellular marrow. Abdominal sonography showed a space-occupying lesion in the spleen which was suspected as malignant tumor. Splenectomy was performed and histologic findings were d...

Traumatic intracranial pseudoaneurysm is a rare complication of blunt trauma. It is even more rare when it presents as epistaxis. Massive epistaxis of a ruptured intracranial internal carotid artery pseudoaneurysm is a major cause of mortality, which requires emergency intervention. We report a case of traumatic intracranial internal carotid artery pseudoaneurysm secondary to skull base fractur...

Epistaxis can be life threatening and may not respond to conventional conservative measures such as packing. In our institution, between 1984 and 1991, we have treated 65 patients with embolization who had epistaxis that did not stop with nasal packing, with a success rate of 90%. This case report illustrates an unusual example of epistaxis due to a right frontal arteriovenous malformation (A V...

BACKGROUND/AIMS Endonasal endoscopic surgery continues to gain acceptance as a minimally invasive, effective approach for benign and malignant pathology of the paranasal sinuses and skull base. Postoperative epistaxis could potentially result in rapid and devastating consequences due to hemorrhage. Our objective was to assess the incidence and causes of epistaxis after endoscopic skull base sur...