background: recent epidemiological studies demonstrate that obesity is associated with an increased risk for breast cancer in women. increased estrogen levels are suggested as one possible explanation, but this does not fully explain the relationship between obesity and breast cancer. one alternative explanation is secretion by adipocytes of metabolites, hormones and cytokines, collectively kno...

Backgrounds and Aims: One member of the cytochrome P450 family, CYP1A1, is one of the genes involved in the metabolism of carcinogens and estrogen, which has been identified to be associated with breast cancer, as well. Considering the known effect of estrogen in different signaling pathways, disorders in these pathways will affect the risk of breast cancer. In this study, we evaluated the rela...

background : migrant studies offer a unique opportunity to analyze variation in disease occurrence due to background factors. the role of environmental and lifestyle exposures are of particular interest in cancer research, and migrant studies can be considered as natural experiments in epidemiological research. large numbers of immigrants from different regions of the world and the availability...

background: the incidence rate of breast cancer has been dramatically increasing since the last decade in iran, and it is now one of the most common female malignant tumors. b?cell lymphoma 2 (bcl2) family is the most important regulator of apoptosis, and ?938c>a single nucleotide polymorphism (snp) of bcl2 gene promoter has been demonstrated to influence breast cancer susceptibility. in this r...

background: il-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. over production of il-10 and elevated number of il-10 generating mononuclear cells in breast tumor tissue has already been shown. objective: to determine the association of il-10 promoter polymorphisms with increased risk of breast cancer and its association with breast cancer prognostic factors. methods: per...

Breast cancer is a malignant tumor and the most common cancer among American women that starts from cells of the breast. The growth of the size of data exceeds the ability of humans to analyze the data. So we need some intelligent machines that can analyze datasets intelligently for us. We propose a Multi Nominal Logit Model to evaluate correlation between risk factors of breast tumor. Our ...

the present research is a field study in order to investigate scale and ways of doing breast self examination (bse). 270 nurses employed by the medical sciences university’s hospitals related to the ministry of health, and medical education in city of tehran are selected and involved in research on the basis of simple random sampling. the data collection tool was a protrayed questionnaire which...