Paramagnetic gold nanostructures were synthesized by combining the paramagnetism of gadolinium with the plasmonic properties of gold nanoparticles and used for dual modal (MRI and optical) imaging and phototherapy of breast cancer cells.

Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs ha...

Breast cancer is the most frequently diagnosed cancer in women worldwide (Globocan, 2008). Successful treatment of breast cancer depends on early diagnosis (Anderson et al., 2011). Mammography is a gold standard for breast cancer screening (Ministry of Health Malaysia Management of breast cancer, 2010; Canadian Task Force on Preventive Health Care, 2011). It plays a major role in the early dete...

Unlike bulk materials, the physicochemical properties of nano-sized metal clusters can be strongly dependent on their atomic structure and size. Over the past two decades, major progress has been made in both the synthesis and characterization of a special class of ligated metal nanoclusters, namely, the thiolate-protected gold clusters with size less than 2 nm. Nevertheless, the determination ...

Introduction: A main choice for cancer treatment is radiotherapy. But, the radiotherapy disadvantage is damages caused by radiation given to normal tissues/organs surrounding cancer. One way to avoid this is via increasing radiosensitization of cancer cells. Gold nanoparticles (GNPs) have shown sensitizing effect on cancer cells by enhancing their absorbed dose. Unlike earlier ...

Breast cancer is a major public health problem worldwide. Important advances have improved survival, but early detection remains the main clinical challenge in reducing mortality. Currently, mammography is the ‘gold standard’ tool for breast cancer screening. However, the search for an early breast cancer detection method is the subject of extensive research. Although infrared imaging or breast...

Breast cancer screening remains a subject of intense and, at times, passionate debate. Mammography has long been the mainstay of breast cancer detection and is the only screening test proven to reduce mortality. Although it remains the gold standard of breast cancer screening, there is increasing awareness of subpopulations of women for whom mammography has reduced sensitivity. Mammography has ...

The properties of metallic clusters of various shapes, on the nanometer length scale, can be dramatically different from the corresponding bulk material due to their very large surface-to-volume ratio. The unique optical and mechanical properties of such nanoclusters hold great promise for the development of nanotechnology. Gold nanoclusters, for example, have found application in such diverse ...

(1R*,4S*,4aR*,9aS*,10S*)-10-Hydroxy-10-phenyl-1,4a,9a,10-tetrahydro-1,4-methanoanthracen-9(4H)-one (1c) was prepared for the elucidation of the reaction mechanism of intramolecular hydroalkoxylation of alkenes catalyzed by gold nanoclusters stabilized by a hydrophilic polymer, poly(N-vinyl-2-pyrrolidone) (Au:PVP). It was found that the reaction proceeded via anti-addition of alcohol to the alke...