Introduction: One of the most common pathologies in neonates is hyperbilirubinemia, which is a good marker for damage to the central nervous system. The sensitivity of the auditory system to bilirubin has been previously documented, with much discrepancy in its effects on Auditory Brainstem Response results. Thus the objective of this study was to evaluate the effects of hyperbilirubinemia on ...

Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been demonstrated in animal models using histological techniques. However, diagnosis of the condition in individual humans is problematic because of (a) test reliability and (b) lack of a gold standard validation measure. Wave I of the transient-evoked auditory brainstem response is a noninvasive electrophysiolo...

Auditory Brainstem Response (ABR) is an auditory evoked potential extracted from ongoing electrical activity in the brain. ABR is especially used for newbornand children hearing screening, auditory threshold estimation, and brainstem lesion detection in response to stimuli such as click sound, tone burst or chirp. In order to support clinical decision making the analysis of ABR signals must exh...

Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB1R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary ...

Cervical somatosensory evoked potentials, brainstem evoked potentials, visual evoked potentials, and the cerebral contingent negative variation were recorded in patients with definite multiple sclerosis before, during, and after spinal cord stimulation. Improvements were seen in the cervical somatosensory and brainstem evoked potentials but neither the visual evoked potential nor the contingent...

A 13-year-old boy with imipramine overdose developed seizures, respiratory arrest, and coma. Abnormalities of oculovestibular reflexes, electroencephalograms, and brainstem auditory evoked potentials were monitored in relation to measurements of drug levels. An alpha-coma electroencephalographic pattern evolved into one evidencing spindle coma and eventually into a normal pattern. Prolonged bra...

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of mortality patients with intractable epilepsy. However, pathogenesis SUDEP seems to be poorly understood. Our previous findings showed that incidence seizure-induced respiratory arrest (S-IRA) was markedly reduced by atomoxetine a murine model. Because central norepinephrine ?-1 receptor (NE?-1R) plays vital role regulating func...

Objective: To evaluate the frequency of hearing impairment and prenatal, antenatal, postnatal variables associated with in neonates at Indus hospital Karachi. Study Design: Prospective, Observational, Cohort study. Setting: Department Pediatrics Neonatology, Sheikh Saeed Memorial Campus (SSMC) Hospital Health Network (IHHN) Karachi, Pakistan. Period: July 2020 to June 2022. Material & Metho...

Introduction Deafness is one of the most important sensory disturbances at birth. Hearing loss can affect the development of speaking and learning during life. Early diagnosis and intervention improve language outcome. The  current study aimed to determine the frequency of profound congenital hearing loss in healthy newborn infants in Fars province. Methods In a multicenter prospective study, f...

Cortical function and related cognitive, language, and communication skills are genetically influenced. The auditory brainstem response to speech is linked to language skill, reading ability, cognitive skills, and speech-in-noise perception; however, the impact of shared genetic and environmental factors on the response has not been investigated. We assessed auditory brainstem responses to spee...