نتایج جستجو برای: brain white matter hyperintensities

تعداد نتایج: 816747  

Journal: :Stroke 2012
Margherita Cavalieri Reinhold Schmidt Christopher Chen Vincent Mok Gabriel R de Freitas Swithin Song Qilong Yi Stefan Ropele Anja Grazer Nina Homayoon Christian Enzinger Katherine Loh Ka Sing Lawrence Wong Adrian Wong Yunyun Xiong Hui Meng Chang Meng Cheong Wong Franz Fazekas John W Eikelboom Graeme J Hankey

BACKGROUND AND PURPOSE Elevated concentrations of homocysteine are associated with cerebral small vessel disease (CSVD). B-vitamin supplementation with folate and vitamins B12 and B6 reduces homocysteine concentrations. In a substudy of the VITAmins TO Prevent Stroke (VITATOPS) trial, we assessed the hypothesis that the addition of once-daily supplements of B vitamins would reduce the progressi...

2013
Akimune Kaga Akiko Saito-hakoda Mitsugu Uematsu Miki Kamimura Junko Kanno Shigeo Kure Ikuma Fujiwara

Several studies have described brain white matter abnormalities on magnetic resonance imaging (MRI) in children and adults with congenital adrenal hyperplasia (CAH), while the brain MRI findings of newborn infants with CAH have not been clarified. We report a newborn boy with CAH who presented brain white matter abnormality on MRI. He was diagnosed as having salt-wasting CAH with a high 17-OHP ...

Journal: :Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition 2010
Colleen M Parks Charles DeCarli Larry L Jacoby Andrew P Yonelinas

Previous studies have indicated that aging is associated with declines in recollection whereas familiarity-based recognition is left largely unaffected. The brain changes underlying these recollection declines are yet not well understood. In the current study we examined the role of white matter integrity as measured by white matter hyperintensities (WMH) on age-related changes in recollection ...

Journal: :Health psychology : official journal of the Division of Health Psychology, American Psychological Association 2014
Tom Booth Rene Mõttus Janie Corley Alan J Gow Ross D Henderson Susana Muñoz Maniega Catherine Murray Natalie A Royle Emma Sprooten Maria C Valdés Hernández Mark E Bastin Lars Penke John M Starr Joanna M Wardlaw Ian J Deary

OBJECTIVE To explore associations between the 5-factor model (FFM; neuroticism, extraversion, openness/intellect, agreeableness, and conscientiousness), personality traits, and measures of whole-brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviors. METHOD Participants from the Lothian Birth Cohort 1936 completed the...

Journal: :Stroke 2013
Hrafnhildur Stefansdottir David O Arnar Thor Aspelund Sigurdur Sigurdsson Maria K Jonsdottir Haukur Hjaltason Lenore J Launer Vilmundur Gudnason

BACKGROUND AND PURPOSE Atrial fibrillation (AF) has been associated with cognitive decline independent of stroke, suggesting additional effects of AF on the brain. We aimed to assess the association between AF and brain function and structure in a general elderly population. METHODS This is a cross-sectional analysis of 4251 nondemented participants (mean age, 76 ± 5 years) in the population-...

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