UNLABELLED We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG. METHODS Eighty-one patients undergoing evaluation for brain tumors were studied. Initially, 30 patients underwent PET with (18)F-FDOPA and (18)F-FDG within the same week. Tracer kinetics in normal brain and tumor tissues were...

BACKGROUND The introduction of fluorescence-guided resection allows a better identification of tumor tissue and its more radical resection. We describe our experience with a modified exoscope to detect 5 ALA-induced fluorescence in neuronavigation-guided brain surgery or biopsy of malignant brain tumors. METHODS Thirty-eight patients with a suspected preoperative diagnosis of high-grade astro...

PURPOSE Our purpose was to evaluate cerebral glioma grade by using normal side creatine (Cr) as an internal reference in multi-voxel 1H-MR spectroscopy. MATERIALS AND METHODS We examined 25 adult patients with glial brain tumors. Ratios of maximum Cho/Cr (normal) (max- Cho/Cr(n)) and minimum NAA/Cr(normal) (min-NAA/ Cr(n)) were determined using Cr levels in the normal parenchyma. In addition, m...

Gliomas account for 70% of primary brain tumors (1). Among the various types of glioma, glioblastoma is the most aggressive astrocytic tumor, being classified grade IV by the World Health Organization (2). Although CT and MRI are indispensable in providing morphologic information, functional imaging using PET plays an important role in grading tumors, delineating tumor boundaries, monitoring tr...

Brain tumor segmentation is an important technique in computer-assisted diagnosis. To improve brain tumor diagnosis, it is necessary to use biochemical information provided by magnetic resonance spectroscopy (MRS). Some of the challenges involved are determining how to combine multimodal signals such as proton MRS and morphological or structural images, then knowing how to use the combined info...

Purpose: Methyl-[C]L-methionine ([C]MET) positron emission tomography (PET) in brain tumors reflects amino acid transport and has been shown to be more sensitive than magnetic resonance imaging in stereotactic biopsy planning. It remains unclear whether the increased [C]MET uptake is limited to solid tumor tissue or even detects infiltrating tumor parts. Experimental Design: In 30 patients, a p...

BACKGROUNDS Neuroendoscopic biopsy is one of the techniques that can be used for histological verification of a suspected brain tumor. The use of neuroendoscopy is particularly useful for cystic tumors and para- and intraventricular brain tumors that are risky for stereotactic biopsy. The technique of navigated neuroendoscopy enables biopsy sampling under visual control, haemostasis of biopsy s...

OBJECTIVE  To determine the characteristics and prognosis of brain metastasised HER-2 positive breast cancer (BC) patients. STUDY DESIGN Descriptive study. PLACE AND DURATION OF Ankara Oncology Training Research Hospital, Turkey between 2000 2019. METHODOLOGY BC patients were analysed retrospectively 105 included in Age 18 years over, BC, with BM (brain metastases) inclusion criteria. Patients ...

BACKGROUND AND PURPOSE Dynamic contrast-enhanced MR imaging may be used to quantify tissue fractional blood volume (fBV) and microvascular permeability. We tested this technique in patients with brain tumors to assess whether these measurements correlate with tumor histologic grade. METHODS Twenty-two patients with newly diagnosed gliomas underwent MR imaging followed by surgery. Imaging cons...