A prototype clinical brain single-photon emission computed tomography (SPECT) insert has been designed for use in simultaneous SPECT/MRI. The system utilizes novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. statistical algorithm developed determine depth-of-interaction (DOI) with a view improving image performa...

OBJECTIVE The diagnosis and management of mild traumatic brain injury continues to be a subject of debate, with varying opinions regarding the extent to which organically based impairments vs the impact of other stressors cause ongoing disability. The aim of this study was to elucidate the possible abnormalities in benzodiazepine receptor uptake in the brains of patients with mild traumatic bra...

Introduction: In this study the evaluation of a Platelet-based Maximum Penalized Likelihood Estimation (MPLE) for denoising SPECT images was performed and compared with other denoising methods such as Wavelets or Butterworth filtration. Platelet-based MPLE factorization as a multiscale decomposition approach has been already proposed for better edges and surfaces representation due to Poisson n...

BACKGROUND AND PURPOSE Tinnitus is associated with an increased activity in central auditory system as demonstrated by neuroimaging studies. Brain perfusion scanning using single photon emission computed tomography (SPECT) was done to understand the pattern of brain blood perfusion of tinnitus subjects and find the areas which are mostly abnormal in these patients. MATERIALS AND METHODS A num...

As the world's population ages, the number of patients with Alzheimer's disease (AD) is predicted to increase rapidly. The presence of neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau protein, is one of the neuropathological hallmarks of AD brain. Since the presence of NFTs is well correlated with neurodegeneration and cognitive decline in AD, imaging of tau using positron em...

A 62-y-old woman was found to have a lung mass and a brain mass. The brain mass was resected, and the histopathologic findings were suggestive of a gastrointestinal primary tumor with neuroendocrine features. She was referred for an 111In-octreotide SPECT/CT scan to evaluate for somatostatin-avid disease. After injection of 222 MBq (6 mCi) of 111In-octreotide, planar SPECT images (Fig. 1A) and ...

Types of imaging Brain imaging techniques currently used in the UK for the clinical assessment of dementia are grouped into three categories: structural, functional and molecular. Structural imaging includes computed tomography (CT) and magnetic resonance imaging (MRI). The images produced by these methods allow one to see the anatomical ‘structure’ of cerebral tissue. They are used to detect a...

The past four decades have seen enormous efforts placed on a search for molecular markers of schizophrenia using positron emission tomography (PET) and single photon computed (SPECT). In this narrative review, we cast broad net to define summarize what researchers learned about from imaging studies. Some PET studies brain energy metabolism with the glucose analogue FDGhave shown hypofrontality ...

The lipophilic neutral complex [99mTc][TcO(MRP20)] [MRP20 is (N-(2(1H pyrolylmethyl]N'-(4-pentene-3-one-2)ethane-1,2-diamine)] is known to cross the blood-brain barrier in non-primate animals. We report here its in vivo biodistribution, radiation dosimetry, and single-photon emission computed tomography (SPECT) characteristics in man. Following i.v. administration of 15-25 mCi of the tracer, th...