BACKGROUND N-terminal pro-brain-type natriuretic peptide (NT-proBNP) is currently used as a surrogate marker for disease severity in pulmonary hypertension (PH). However, NT-proBNP tends to have a high variability and may insufficiently correlate with hemodynamics and exercise capacity. METHODS To investigate the association of NT-proBNP with hemodynamics and cardio-pulmonary exercise testing...

Background There are scanty data of right ventricular dysfunction markers after major pulmonary resection. Objective To study the changes plasma level N-terminal pro-brain natriuretic peptide (NT-proBNP) and its association with artery pressure (PAP) as in patients who underwent bronchoplastic lobectomy or pneumonectomy. Material Methods The population consisted 36 aged 40–65 resection for lung...

BACKGROUND Measurement of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is useful for evaluating patients with heart failure (HF). METHODS We evaluated the performance of a new automated NT-proBNP assay. RESULTS The VITROS NT-proBNP assay had mean within-run and total imprecision of 1.0% and 3.4% at NT-proBNP concentrations from 67-27,500 ng/l. Acceptable linearity, functional/a...

†Departments of Paediatrics, ‡Medicine, §Chemical Pathology, College of Medicine, University of Lagos, Nigeria. *Correspondence: E. N. Ekure, Departments of Paediatrics, College of Medicine, University of Lagos, Nigeria. Email addresses: ENE: [email protected] CAN: [email protected] JNA: [email protected] AM: [email protected] JO: [email protected] Abbreviations: CHF, Congestive...

1. Brain natriuretic peptide is a new natriuretic hormone with striking similarity to atrial natriuretic peptide, but there are no previous data concerning its clearance in man. Two pathways of clearance for atrial natriuretic peptide are recognized: degradation by neutral endopeptidase and binding to atrial natriuretic peptide clearance receptors. We have examined the effect of candoxatril, an...

OBJECTIVE In children treated for univentricular heart (UVH), prospective evaluation of serum levels of N-terminal proatriopeptide (ANPN) and N-terminal pro-brain natriuretic peptide (NT-proBNP) was performed. METHODS Serum samples were analysed in 19 children before the first operation, before the bi-directional Glenn (BDG) operation, at age 1 year and before total cavopulmonary connection (...

BACKGROUND Non-ST-segment elevation acute coronary syndrome is associated with elevation of brain natriuretic peptide and markers of myocardial necrosis, although its relationship with the TIMI score and left ventricular function are largely unknown. OBJECTIVE To evaluate the correlation between plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and markers of myocardial necrosis [cr...

OBJECTIVE To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality. DESIGN Prospective pilot study. SUBJECTS AND METHODS In 19 patients planned for a lower limb amputation for non-reconstructable peripheral arterial disease ...

The cardiac natriuretic peptides, ANP (atrial natriuretic peptide) and BNP (brain natriuretic peptide), are secreted by the heart in proportion to cardiac transmural pressures. They possess a wide range of effects in multiple tissues facilitating overall pressure/volume homoeostasis. The close relationship between plasma concentrations of these peptides and 'cardiac load' has led to their use a...

OBJECTIVES This study sought to investigate plasma levels of circulating cardiac natriuretic peptides, atrial natriuretic peptide (ANP) and B-type or brain natriuretic peptide (BNP), in the general community, focusing on their relative differences in worsening human hypertension. BACKGROUND Although ANP and BNP are well-characterized regulators of blood pressure in humans, little is known at ...