Brain metastasis is common in patients with melanoma and represents a significant cause of morbidity and mortality. There have been no specific randomized trials for patients with melanoma brain metastasis, so treatment is based on management of brain metastasis in general and requires multidisciplinary expertise including radiation oncology, neurosurgery, medical oncology, and palliative care....

We report the first case of 10-year disease-free survival in a patient with small cell lung cancer (SCLC) with brain metastasis. A 63-year-old man was found to have SCLC with brain metastasis and underwent chemoradiotherapy. Radiation therapy was delivered to the brain, lungs, mediastinum and supraclavicular fossa. Chemotherapy regimen mainly consisted of etoposide-plus-cisplatin. The patient h...

The present investigation was undertaken to determine whether the failure of brain tumors to metastasize was related to local conditions at the site of origin. Three hamster tumors and two rabbit tumors, known to be capable of metastasis, were trans planted to the brains of animals of the same species. The tumors grew rapidly but killed the bearers before sufficient time had elapsed to allow th...

Brain metastasis is a major cause of systemic cancer morbidity and mortality. Many factors participate in the development and maintenance of brain metastases. The survival of the metastasis depends upon crucial interactions between tumour cells and the brain microenvironment during its development at the new site. This review focuses on the pathobiological mechanisms involved in the establishme...

Adenoid cystic carcinoma is a rare malignant neoplasm of the salivary gland. Salivary gland neoplasms constitute 3% cancers all sites, which, 10–15% are malignant. Though adenoid most common tumor submandibular, sublingual and minor glands, it accounts for only 15% parotid cancers. They generally slow-growing spread relentlessly to adjacent structures. Hematogenous more than lymphatic spread, s...

introduction: meningioma is a benign and slowly-growing tumor that is responsible for 20% of brain neoplasms. it can be accompanied by some genetic disorders such as neurofibromatosis type 2 and is more common among women. as a space occupying lesion, it produces a wide range of signs and symptoms by compressing the adjacent and underlying tissues in the brain. trauma and viruses are possible e...

Despite major therapeutic advances in the management of patients with systemic malignancies, management of brain metastases remains a significant challenge. These patients often require multidisciplinary care that includes surgical resection, radiation therapy, chemotherapy, and targeted therapies. Complex decisions about the sequencing of therapies to control extracranial and intracranial dise...

Aggressive treatment, including resection of both metastasis and primary tumor, has been studied for non-small cell lung cancer patients with synchronous solitary brain metastasis. Involvement of mediastinal lymph nodes is considered a poor prognostic factor and a contraindication to surgical resection of the primary lung tumor after treatment for brain metastasis. Here we present the case of a...

We aimed to evaluate the role of pretreatment carcinoembryonic antigen (CEA) and platelet to lymphocyte ratio (PLR) in predicting brain metastasis after radical surgery for lung adenocarcinoma patients. The records of 103 patients with completely resected lung adenocarcinoma between 2013 and 2014 were reviewed. Clinicopathologic characteristics of these patients were assessed in the Cox proport...

It is unclear whether hemorrhage of brain metastasis is a poor prognostic factor in patients with hepatocellular carcinoma. We conducted a retrospective cohort study to compare overall survival between hemorrhage and no-hemorrhage groups of hepatocellular carcinoma patients with brain metastasis. Hepatocellular carcinoma patients with brain metastasis treated between June 2000 and June 2016 at ...