نتایج جستجو برای: brain iron accumulation

تعداد نتایج: 749017  

Journal: :The Journal of nutrition 2011
Wint Nandar James R Connor

Iron accumulation in the brain and increased oxidative stress are consistent observations in many neurodegenerative diseases. Thus, we have begun examination into gene mutations or allelic variants that could be associated with loss of iron homeostasis. One of the mechanisms leading to iron overload is a mutation in the HFE gene, which is involved in iron metabolism. The 2 most common HFE gene ...

2016
Moones Heidari Sam H. Gerami Brianna Bassett Ross M. Graham Anita C.G. Chua Ritambhara Aryal Michael J. House Joanna F. Collingwood Conceição Bettencourt Henry Houlden Mina Ryten John K. Olynyk Debbie Trinder Daniel M. Johnstone Elizabeth A. Milward

We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe (-/-) xTfr2 (mut) mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family 'neurodegeneration with brain iron accumulation' (NBIA). Expanded data mining and ontolog...

2012
Robert Fekete

Neurodegeneration with brain-iron accumulation (NBIA) encompasses a family of neurodegenerative disorders connected by evidence of abnormal brain iron deposition. Advances in imaging and genetic testing expanded the clinical spectrum of these disorders. Here, a case of parkinsonism and dystonia with orofacial stereotypies is presented. While the patient was initially diagnosed with Parkinson's ...

Journal: :Neurology 2013
Natalie E Parks Robert A Vandorpe Jeremy J Moeller

A 55-year-old African Canadian man with insulin-dependent diabetes mellitus and alcohol abuse presented with diabetic ketoacidosis. Progressive cognitive decline over the previous 5 years resulted in long-term care placement. Aside from pigmentary retinopathy, general examination was unremarkable. MRI demonstrated iron accumulation in the brain (figure 1) and liver (figure 2A). Ceruloplasmin, a...

2017
Gergely Darnai Szilvia Anett Nagy Réka Horváth Péter Ács Gábor Perlaki Gergely Orsi Norbert Kovács Anna Altbäcker Enikő Plózer Dalma Tényi Rita Weintraut Attila Schwarcz Flóra John Eszter Varga Tamás Bereczkei Zsófia Clemens Sámuel Komoly József Janszky

Abnormally high deposition of iron can contribute to neurodegenerative disorders with cognitive impairment. Since previous studies investigating cognition-brain iron accumulation relationships focused on elderly people, our aim was to explore the association between iron concentration in subcortical nuclei and two types of memory performances in a healthy young population. Gender difference was...

2014
Grazia Isaya

Growing evidence supports a role for mitochondrial iron metabolism in the pathophysiology of neurodegenerative disorders such as Friedreich ataxia (FRDA) and Parkinson disease (PD) as well as in the motor and cognitive decline associated with the aging process. Iron-sulfur enzyme deficits and regional iron accumulation have been observed in each of these conditions. In spite of significant etio...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Ana M Daugherty E Mark Haacke Naftali Raz

The accumulation of non-heme iron in the brain has been proposed as a harbinger of neural and cognitive decline in aging and neurodegenerative disease, but support for this proposal has been drawn from cross-sectional studies, which do not provide valid estimates of change. Here, we present longitudinal evidence of subcortical iron accumulation in healthy human adults (age 19-77 at baseline). W...

2010
Gabriela A. Salvador Romina M. Uranga Norma M. Giusto

The accumulation of transition metals (e.g., copper, zinc, and iron) and the dysregulation of their metabolism are a hallmark in the pathogenesis of several neurodegenerative diseases. This paper will be focused on the mechanism of neurotoxicity mediated by iron. This metal progressively accumulates in the brain both during normal aging and neurodegenerative processes. High iron concentrations ...

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