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Brain is the most sophisticated and important organ of our body. Together with spinal cord it control all actions, functions voluntary or involuntary plays a vital role in managing various systems It has its own protective barriers that protects brain from pathogens toxins may cause harm. These are namely Blood-Brain barrier Blood-Cerebrospinal Fluid Barrier. The highly lipophilic nature these ...

Blood–Brain Barrier In article number 2100812 by Smriti Singh, Agnieszka Morgenroth, and co-workers, Matrix metalloprotease (MMP) sensitive nanogels are synthesized for effective delivery of a radiopharmaceutical ([125I]ITdU) across the blood-brain barrier (BBB). The show efficient transcytosis in vitro model BBB co-cultured with glioblastoma cells. Once transcytosed, degrade an up-regulated MM...

The delivery of cancer chemotherapy to treat brain tumors remains a challenge, in part, because of the inherent biological barrier, the blood-brain barrier. While its presence and role as a protector of the normal brain parenchyma has been acknowledged for decades, it is only recently that the important transporter components, expressed in the tightly knit capillary endothelial cells, have been...

Chronic sleep restriction induces blood-brain barrier disruption and increases pro-inflammatory mediators in rodents. Those inflammatory mediators may modulate the blood-brain barrier and constitute a link between sleep loss and blood-brain barrier physiology. We propose that adenosine action on its A2A receptor may be modulating the blood-brain barrier dynamics in sleep-restricted rats. We adm...

Ursodeoxycholic acid and its main conjugate glycoursodeoxycholic acid are bile acids with neuroprotective properties. Our previous studies demonstrated their anti-apoptotic, anti-inflammatory, and antioxidant properties in neural cells exposed to elevated levels of unconjugated bilirubin (UCB) as in severe jaundice. In a simplified model of the blood-brain barrier, formed by confluent monolayer...

Sysyn, Gregory D., Katherine H. Petersson, Clifford S. Patlak, Grazyna B. Sadowska, and Barbara S. Stonestreet. Effects of postnatal dexamethasone on bloodbrain barrier permeability and brain water content in newborn lambs. Am J Physiol Regulatory Integrative Comp Physiol 280: R547–R553, 2001.—We showed that antenatal corticosteroids reduced blood-brain barrier permeability in fetuses at 60 and...

Sysyn, Gregory D., Katherine H. Petersson, Clifford S. Patlak, Grazyna B. Sadowska, and Barbara S. Stonestreet. Effects of postnatal dexamethasone on bloodbrain barrier permeability and brain water content in newborn lambs. Am J Physiol Regulatory Integrative Comp Physiol 280: R547–R553, 2001.—We showed that antenatal corticosteroids reduced blood-brain barrier permeability in fetuses at 60 and...

BACKGROUND AND PURPOSE The integrity of the blood-brain barrier may play an important pathophysiological role during postischemic reperfusion. To determine the factors that lead to exacerbation of brain injury by reperfusion, we investigated changes in cerebral blood flow, blood-brain barrier permeability, edema formation, and infarction in permanent or temporary middle cerebral artery occlusio...