BACKGROUND The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na+,K+-ATPase and mutated adducin. Rostafuroxin lowered blood pressure (BP) in some animal models and in humans. METHODS OASIS-HT consisted o...

INTRODUCTION Resistant hypertension is inadequately controlled blood pressure (BP) despite treatment with at least three BP-lowering drugs. A popular hypothesis is that resistant hypertension is due to excessive Na(+)-retention, and that 'further diuretic therapy' will be superior to alternative add-on drugs. METHODS AND ANALYSIS Placebo-controlled, random crossover study of fourth-line treat...

Objectives To determine the effects of exergaming on quality life (QoL), motor, and clinical symptoms in subacute stroke patients. Design A pseudorandomized controlled trial, using a before-after test design. Setting University hospital. Participants Subacute, ischemic outpatients (N=3857), 680 whom were randomized 641 completed study. Interventions We determined 5 times week twice daily (EX2; ...

Figure 1. Genetic Analysis of BCL10 in Germ Cell Tumors (GCTs) and B Cell Lymphomas (A) PCR-SSCP analysis. (a) and (c), GCT; (b) and (d), lymphoma. (a) and (b), exon 1; (c) and (d), exon 3.2. Arrows indicate conformational changes. N, normal; T, tumor; CL, cell line; tumor numbers are indicated on top. (B) PCR sequence analysis. (a) and (b), Tera-1; (c), GCT-44; (d) and (e), Tera-2; (f), T-243A...

Background: Consumption of dark chocolate has been often hypothesized to have a role in the prevention of chronic diseases. The objective of this study was to investigate the effects of consumption of dark chocolate (DC) on serum oxidative stress and blood pressure (BP) in patients with metabolic syndrome (MetS). Methods: An 8-week parallel randomized clinical trial involving 114 patients with ...

BACKGROUND Several studies have assessed the relationship between the angiotensin-converting enzyme (ACE) I/D or angiotensin II type 1 receptor (AT(1)R)-A C polymorphisms and blood pressure (BP). Since most data have been obtained in selected populations, the present study was performed in a healthy normotensive primary care population. OBJECTIVE To investigate the individual effects of the a...

BACKGROUND Although increased sympathetic nervous system (SNS) activity is commonly associated with major depressive disorder (MDD) and cardiovascular disease (CVD), a biomarker linking these two entities remains elusive. We therefore evaluated the relationship between depressive symptoms and cardiovascular modulation by heart rate variability (HRV), brachial blood pressure (BP), ambulatory BP ...

CONTEXT The clinical use of ambulatory blood pressure (BP) monitoring requires further validation in prospective outcome studies. OBJECTIVE To compare the prognostic significance of conventional and ambulatory BP measurement in older patients with isolated systolic hypertension. DESIGN Substudy to the double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) Trial, started ...

The cardiovascular effects of opioid peptides have been studied. Leucine-enkephalin (Leu-ENK) produced blood pressure (BP) increases following administration into the lateral brain ventricles (i.v.t.), into the cisterna magna (i.c.i.), and following intravenous (i.v.) administration. Heart rate (HR) increases were observed following all routes of administration (threshold for BP and HR effects ...

BACKGROUND Nearly all information processing during cognitive processing takes place during periods of sustained attention. Sustained attention deficit is among the most commonly reported impairments in bipolar disorder (BP). The majority of previous studies have only focused on bipolar I disorder (BP I), owing to underdiagnosis or misdiagnosis of bipolar II disorder (BP II). With the refinemen...