Bone cancer pain is the most severe among cancer pain and is often resistant to current analgesics. Thus, the development of novel analgesics effective at treating bone cancer pain are desired. Platelet-activating factor (PAF) receptor antagonists were recently demonstrated to have effective pain relieving effects on neuropathic pain in several animal models. The present study examined the pain...

Treatment of bone metastases comprises over 10% of the workload of a radiation-oncology center. Bone metastases produce severe pain and immobility, necessitate narcotic use, and reduce the quality of life. A good palliative treatment must be complete, free from side effects and fast; Thus we decided to evaluate Strontium-89 (89Sr) effectivity for palliation of breast and prostate cancer b...

conclusion there are significant differences between vo by different microorganisms that help physician to start empirical medical treatment while waiting to definite diagnosis by blood culture, culture from paravertebral abscess, serology and bone biopsy. spinal osteomyelitis is an uncommon cause of back pain but it has potential to compromise nervous system and even death may occur if it is n...

background: rupture of anterior cruciate ligament (acl) would cause instability and disability and if left untreated. reconstruction is performed by different techniques including patellar bone graft, as the strongest device. application of brace after acl reconstructions has revealed doubtful results.   methods: one hundred acl ruptured patients randomized into two groups were reconstructed wi...

The pain of osteoarthritis (OA) has multifaceted etiologies within and outside the joint. It is believed to be driven by both nociceptive and neuropathic mechanisms, as well as abnormal excitability in the pain pathways of the peripheral and central nervous system. Inflammation in the joint triggers a cascade of events that leads to peripheral sensitization, increased sensitivity of nociceptive...

treatment of bone metastases comprises over 10% of the workload of a radiation-oncology center. bone metastases produce severe pain and immobility, necessitate narcotic use, and reduce the quality of life. a good palliative treatment must be complete, free from side effects and fast; thus we decided to evaluate strontium-89 (89sr) effectivity for palliation of breast and prostate cancer bone me...

background: bone sarcomas are the most common malignancies of bone tissues in children, and are classified intotwo groups as osteosarcoma and ewing’s sarcoma. treatment and prognosis depend on the subtype and grade ofthe tumor. the goal of this study was to evaluate the features bone sarcoma in patients referred to mahak childrenhospital since 2007 to 2009.materials and methods: this was a retr...