Abstract With the aging of population, risk osteoporotic vertebral compression fractures (OVCF) caused by osteoporosis increases rapidly. Surgeons often fill bone defect with injectable polymethylmethacrylate (PMMA) cement through vertebroplasty. However, compared cancellous bone, higher mechanical properties PMMA can easily lead to fracture adjacent cone. Besides, wound infection surgery is al...

An unusual phenomenon is observed for gelatin solutions (1.7-6.8%) in the microemulsion system of 0.3 M bis(2-ethylhexyl)sulfosuccinate sodium salt in isooctane and 14.5% distilled water. Highly viscous gels obtained at temperatures above 30 degreesC become free-flowing liquids at low temperatures (5-10 degreesC). This reversible temperature-dependent sol-gel transition phenomenon is used to im...

Osteochondral injuries remain difficult to repair. We developed a novel photo-cross-linkable furfurylamine-conjugated gelatin (gelatin-FA). Gelatin-FA was rapidly cross-linked by visible light with Rose Bengal, a light sensitizer, and was kept gelled for 3 weeks submerged in saline at 37°C. When bone marrow-derived stromal cells (BMSCs) were suspended in gelatin-FA with 0.05% Rose Bengal, appro...

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to the irreversible destruction of cartilage and bone. An important step in the destruction of tissue is the degradation of extracellular matrix (ECM), whose major components are type II collagen and aggrecan in cartilage, and type I collagen in bone. The synovial fluid of RA patients often contains high concentrations of pr...

CCN family protein 2/connective tissue growth factor (CCN2/CTGF) is a unique molecule that promotes the entire endochondral ossification process and regeneration of damaged articular cartilage. Also, CCN2 has been shown to enhance the adhesion and migration of bone marrow stromal cells as well as the growth and differentiation of osteoblasts; hence, its utility in bone regeneration has been sug...

scaffold design has pivotal role in tissue engineering. in the present study, we modified the surface of electrospun poly(caprolactone) (pcl) nanofibers to improve their compatibility with living medium and to show the potential application of pcl nanofibers as a artificial extracellular matrix using in tissue-engineering. pcl nanofibers were fabricated by electrospinning method. to graft gelat...

BACKGROUND The matrix-degrading proteinases are believed to play an important role in the invasion and metastasis of hepatocellular carcinoma (HCC), but no one has ever seen the in situ matrix-degrading activity in HCCs. PURPOSE To demonstrate the cellular localization of actual gelatinolytic activity and to investigate the invasive potential of human HCC. EXPERIMENTAL DESIGN HCC cases (30)...

Need for regeneration and repair of nasal tissues occurs as a consequence several pathologies affecting the nose, including, but not limited to infective diseases, traumas tumor resections. A platform tissue was set up using poly(vinyl alcohol)/gelatin sponges with 20%–30% (w/w) gelatin content be used scaffolds, their intrinsic hydrophilic, cell adhesive shape recovery properties. We propose m...