BACKGROUND Non adherent bone marrow derived cells (NA-BMCs) have recently been described to give rise to multiple mesenchymal phenotypes and have an impact in tissue regeneration. Therefore, the effects of murine bone marrow derived NA-BMCs were investigated with regard to engraftment capacities in allogeneic and syngeneic stem cell transplantation using transgenic, human CD4(+), murine CD4(-/-...

introduction: the thalassamias refer to a diverse group of hemoglobin disorders characterized by a reduced synthesis of  one or more of globin chains (α,β, γ, δβ,γδβ, δ and εγδβ).the main cure available today for thalassamia is bone marrow transplantation (bmt)  from compatible donor.on december 3, 1981 a 14-month-old child with β-thalassemia major recieved bmt from his hla-identical sister in ...

BACKGROUND CD40 ligand (CD40L) deficiency is a rare X linked immunodeficiency disorder leading to recurrent bacterial infection, with cryptosporidial enteritis and subsequent hepatic cirrhosis. Bone marrow transplantation offers the only cure. OBJECTIVE To analyse retrospectively the outcome of bone marrow transplantation for this condition in one centre. DESIGN A retrospective case note an...

By H. S. WINCHELL, MYRON POLLYCOVE, W. D. LOUGHMAN AND J. H. LAWRENCE R ELATIVELY selective beta irradiation of the lymphatic system in the dog has been achieved with internally administered Yttrium90 chelated with diethylene triamine penta-acetic acid ( Y90-DTPA) . Intravenous injection of Y#{176}#{176}-DTPA followed by continuous intravenous infusion of the animal’s own urine containing the e...

Bone marrow transplantation in man.-Georges Math#{233} ( Paris ) opened the discussion by reviewing the Yugoslavian reactor accident and discussing the clinical management of the exposed individuals. Adult homologous bone marrow or homologous fetal liver was used to treat five of the victims. One man died and the others survived with evidence of temporary transplantation of red blood cell-formi...

Bone marrow transplantation in man.-Georges Math#{233} ( Paris ) opened the discussion by reviewing the Yugoslavian reactor accident and discussing the clinical management of the exposed individuals. Adult homologous bone marrow or homologous fetal liver was used to treat five of the victims. One man died and the others survived with evidence of temporary transplantation of red blood cell-formi...

Allogeneic bone marrow transplantation (BMT) after high-dose, marrow-ablative chemoradiotherapy has been established as the treatment of choice for various hematologic, neoplastic, and congenital disorders. The most common type of marrow graft is an allogeneic one from a sibling donor who has compatible human leukocyte antigen (HLA). Only 30% of patients requiring allogeneic BMT have an HLA-com...

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...

bone through a needle was worked out in man in 1956 by the late Professor Humble at Westminster, before the Americans and before the French. Initially the sternum was used but it is a little thin and dangerous and he decided to go for the iliac crest and he worked out a technique by which a pint of bone marrow could be sucked out through four holes and given intravenously. This was the start of...

Bone marrow transplantation is increasingly used to treat a broad spectrum of human diseases including aplastic anemia, leukemia, solid tumors, immune and genetic disorders. In certain circumstances the role of transplantation is reasonably well established, such as aplastic anemia and resistant leukemia. In other circumstances there is controversey as to the role of transplantation such as leu...